PMID- 16101513
OWN - NLM
STAT- MEDLINE
DCOM- 20050908
LR  - 20191109
IS  - 1566-5232 (Print)
IS  - 1566-5232 (Linking)
VI  - 5
IP  - 4
DP  - 2005 Aug
TI  - Altering the tropism of lentiviral vectors through pseudotyping.
PG  - 387-98
AB  - The host range of retroviral vectors including lentiviral vectors can be expanded 
      or altered by a process known as pseudotyping. Pseudotyped lentiviral vectors 
      consist of vector particles bearing glycoproteins (GPs) derived from other 
      enveloped viruses. Such particles possess the tropism of the virus from which the 
      GP was derived. For example, to exploit the natural neural tropism of rabies 
      virus, vectors designed to target the central nervous system have been 
      pseudotyped using rabies virus-derived GPs. Among the first and still most widely 
      used GPs for pseudotyping lentiviral vectors is the vesicular stomatitis virus GP 
      (VSV-G), due to the very broad tropism and stability of the resulting 
      pseudotypes. Pseudotypes involving VSV-G have become effectively the standard for 
      evaluating the efficiency of other pseudotypes. This review samples a few of the 
      more prominent examples from the ever-expanding list of published lentiviral 
      pseudotypes, noting comparisons made with pseudotypes involving VSV-G in terms of 
      titer, viral particle stability, toxicity, and host-cell specificity. Particular 
      attention is paid to publications of successfully targeting a specific organ or 
      cell types.
FAU - Cronin, James
AU  - Cronin J
AD  - Gene Therapy Program, Louisiana State University Health Sciences Center, New 
      Orleans, 70112, USA.
FAU - Zhang, Xian-Yang
AU  - Zhang XY
FAU - Reiser, Jakob
AU  - Reiser J
LA  - eng
GR  - R01 NS044832/NS/NINDS NIH HHS/United States
GR  - NS044832/NS/NINDS NIH HHS/United States
GR  - R01 NS044832-02/NS/NINDS NIH HHS/United States
GR  - R01 NS044832-03/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United Arab Emirates
TA  - Curr Gene Ther
JT  - Current gene therapy
JID - 101125446
RN  - 0 (G protein, vesicular stomatitis virus)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
EIN - Curr Gene Ther. 2005 Oct;5(5):531
MH  - Animals
MH  - Genetic Therapy/methods
MH  - *Genetic Vectors/chemistry/physiology
MH  - *Glycoproteins
MH  - HIV-1/genetics
MH  - Humans
MH  - Lentivirus/chemistry/*genetics/physiology
MH  - Membrane Glycoproteins
MH  - Transfection
MH  - Viral Envelope Proteins
PMC - PMC1368960
MID - NIHMS6191
EDAT- 2005/08/17 09:00
MHDA- 2005/09/09 09:00
PMCR- 2006/02/15
CRDT- 2005/08/17 09:00
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/09/09 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
PHST- 2006/02/15 00:00 [pmc-release]
AID - 10.2174/1566523054546224 [doi]
PST - ppublish
SO  - Curr Gene Ther. 2005 Aug;5(4):387-98. doi: 10.2174/1566523054546224.