PMID- 16101573
OWN - NLM
STAT- MEDLINE
DCOM- 20050921
LR  - 20211203
IS  - 1389-2002 (Print)
IS  - 1389-2002 (Linking)
VI  - 6
IP  - 4
DP  - 2005 Aug
TI  - Animal models of xenobiotic receptors.
PG  - 341-55
AB  - Retinoid X receptors (RXRs) form heterodimers with pregnane X receptor (PXR) and 
      constitutive androstane receptor (CAR), two prototypical xenobiotic receptors, 
      and mediate metabolism of xenobiotics (foreign compounds) and endobiotics 
      (endogenous compounds). Establishment of gene knockout and transgenic mouse 
      models of RXRs, PXR, and CAR greatly enhanced the study of the biology of nuclear 
      receptors, leading to considerable research progress in understanding the 
      molecular mechanism underlying the nuclear receptor-mediated pathways in 
      xenobiotic and endobiotic metabolism. These animal models are widely used in 
      screening nuclear receptor ligands, identifying nuclear receptor target genes, 
      and defining physiological and pharmacological pathways mediated by these 
      xenobiotic nuclear receptors. In addition, "humanized" PXR and CAR mouse models, 
      which avoid species specificity, provide valuable tools for investigating human 
      xenobiotic response. Moreover, generations of multiple gene knockout mouse models 
      further allow us to identify unique and redundant pathways mediated by each 
      xenosensor. In this article, we review the progress made by using animal models 
      of RXRs, PXR, and CAR in understanding the biological functions of these nuclear 
      receptors in physiology, pharmacology, and pathology.
FAU - Dai, Guoli
AU  - Dai G
AD  - Department of Pharmacology, Toxicology and Therapeutics, University of Kansas 
      Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
FAU - Wan, Yu-Jui Yvonne
AU  - Wan YJ
LA  - eng
GR  - R01 CA053596/CA/NCI NIH HHS/United States
GR  - AA14147/AA/NIAAA NIH HHS/United States
GR  - CA53596/CA/NCI NIH HHS/United States
GR  - P20RR016475/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Curr Drug Metab
JT  - Current drug metabolism
JID - 100960533
RN  - 0 (Constitutive Androstane Receptor)
RN  - 0 (Pregnane X Receptor)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Drug)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animals
MH  - Constitutive Androstane Receptor
MH  - Hepatocytes/metabolism
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Models, Biological
MH  - Pregnane X Receptor
MH  - Receptors, Cytoplasmic and Nuclear/genetics/metabolism
MH  - Receptors, Drug/genetics/*metabolism
MH  - Receptors, Steroid/genetics/metabolism
MH  - Transcription Factors/genetics/metabolism
MH  - Xenobiotics/*metabolism
RF  - 87
EDAT- 2005/08/17 09:00
MHDA- 2005/09/22 09:00
CRDT- 2005/08/17 09:00
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/09/22 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - 10.2174/1389200054633862 [doi]
PST - ppublish
SO  - Curr Drug Metab. 2005 Aug;6(4):341-55. doi: 10.2174/1389200054633862.