PMID- 16101757
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20191210
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 22
IP  - 3
DP  - 2005 Aug
TI  - Requirement of NMDA receptor reactivation for consolidation and storage of 
      nondeclarative taste memory revealed by inducible NR1 knockout.
PG  - 755-63
AB  - We employed an inducible, reversible and region-specific gene knockout technique 
      to investigate the requirements for cortical NMDA receptors (NMDAR) during the 
      various stages (acquisition, consolidation and storage, and retrieval) of 
      nondeclarative, hippocampal-independent memory in mice using a conditioned taste 
      aversion memory paradigm. Here we show that temporary knockout of the cortical 
      NMDAR during either the learning or postlearning consolidation stage, but not 
      during the retrieval stage, causes severe performance deficits in the 1-month 
      taste memory retention tests. More importantly, we found that the consolidation 
      and storage of the long-term nondeclarative taste memories requires cortical 
      NMDAR reactivation. Thus, the dynamic engagement of the NMDAR during the 
      postlearning stage leads us to postulate that NMDAR reactivation-mediated 
      synaptic re-entry reinforcement is crucial for overcoming the destabilizing 
      effects intrinsic to synaptic protein turnover and for achieving consolidation 
      and storage of nondeclarative memories in the brain.
FAU - Cui, Zhenzhong
AU  - Cui Z
AD  - Center for Systems Neurobiology, Department of Pharmacology, Boston University, 
      Boston, MA 02118, USA.
FAU - Lindl, Kathryn A
AU  - Lindl KA
FAU - Mei, Bing
AU  - Mei B
FAU - Zhang, Shuqing
AU  - Zhang S
FAU - Tsien, Joe Z
AU  - Tsien JZ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Sweetening Agents)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 149137-54-2 (Lox protein, mouse)
RN  - EC 1.4.3.13 (Protein-Lysine 6-Oxidase)
RN  - EC 2.7.7.- (Cre recombinase)
RN  - EC 2.7.7.- (Integrases)
RN  - FST467XS7D (Saccharin)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/drug effects/*physiology
MH  - Behavior, Animal/physiology
MH  - Cerebral Cortex/anatomy & histology/*physiology
MH  - Conditioning, Psychological
MH  - Extracellular Matrix Proteins/genetics/metabolism
MH  - Gene Expression Regulation/physiology
MH  - Green Fluorescent Proteins/biosynthesis
MH  - Integrases/genetics
MH  - Lithium Chloride/pharmacology
MH  - Long-Term Potentiation/drug effects/physiology
MH  - Memory/drug effects/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Protein-Lysine 6-Oxidase/genetics/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/deficiency/genetics/*physiology
MH  - Saccharin/pharmacology
MH  - Sweetening Agents/pharmacology
MH  - Taste/drug effects/*physiology
MH  - Time Factors
EDAT- 2005/08/17 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/08/17 09:00
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - EJN4257 [pii]
AID - 10.1111/j.1460-9568.2005.04257.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2005 Aug;22(3):755-63. doi: 10.1111/j.1460-9568.2005.04257.x.