PMID- 16102736
OWN - NLM
STAT- MEDLINE
DCOM- 20051121
LR  - 20191210
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1056
IP  - 1
DP  - 2005 Sep 14
TI  - Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a 
      mammalian tachykinin peptide, on nociception in mice.
PG  - 51-8
AB  - Rat/mouse hemokinin 1 (r/m HK-1) is a novel tachykinin peptide whose biological 
      functions are not fully understood. This work was designed to observe the effects 
      of r/m HK-1 in pain modulation at supraspinal level in mice using tail-flick 
      test. Intracerebroventricular (i.c.v.) administration of r/m HK-1 (0.1, 0.3, 1, 3 
      nmol/mouse) dose-dependently induced potent analgesic effect (ED(50) = 0.2877 
      nmol/mouse). When r/m HK-1 co-injected (i.c.v.) with SR140333 (a selective NK(1) 
      receptor antagonist), SR140333 could fully antagonize the analgesic effect of r/m 
      HK-1. The maximal analgesic effect of r/m HK-1 (3 nmol/mouse) could also be 
      reversed by naloxone (i.p., 2 mg/kg). However, i.c.v. low dose administration of 
      r/m HK-1 (10, 3, 1 pmol/mouse) induced hyperalgesia with a "U" shape curve, which 
      means that the maximal hyperalgesic effect appeared at 3 pmol/mouse, and this 
      effect of r/m HK-1 could also be fully blocked by SR140333. Interestingly, 
      [Nphe(1)]NC(1-13)NH(2), a selective opioid receptor like-1 (ORL-1) receptor 
      antagonist, could fully reverse the maximal hyperalgesic effect of r/m HK-1 (3 
      pmol/mouse). In addition, when r/m HK-1 co-injected (i.c.v.) with SR48968 (a 
      selective NK(2) receptor antagonist), SR48968 could hardly affect the nociceptive 
      effects of r/m HK-1 either at nanomole concentration or at picomole 
      concentration. These findings suggested that r/m HK-1 might play an important 
      role in pain modulation at supraspinal level in mice and these effects were first 
      elicited through the activation of NK(1) receptor, subsequently, whether 
      activation of the classical opioid receptor or the ORL1 receptor depending on the 
      dose of i.c.v. administration of r/m HK-1.
FAU - Fu, Cai-Yun
AU  - Fu CY
AD  - Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou 
      University, 222 Tian Shui South Road, Lanzhou 730000, People's Republic of China.
FAU - Kong, Zi-Qing
AU  - Kong ZQ
FAU - Wang, Kai-Rong
AU  - Wang KR
FAU - Yang, Qi
AU  - Yang Q
FAU - Zhai, Kui
AU  - Zhai K
FAU - Chen, Qiang
AU  - Chen Q
FAU - Wang, Rui
AU  - Wang R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Benzamides)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (HJV protein, mouse)
RN  - 0 (Hemochromatosis Protein)
RN  - 0 (Membrane Proteins)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Quinuclidines)
RN  - 0 (cyclo(N-benzylglycyl-phenylalanyl-tryptophyl-lysyl-threonyl-phenylalanyl))
RN  - 153050-21-6 (SR 140333)
RN  - 36B82AMQ7N (Naloxone)
RN  - 51110-01-1 (Somatostatin)
RN  - 720U2QK8I5 (SR 48968)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Benzamides/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - GPI-Linked Proteins
MH  - Hemochromatosis
MH  - Hemochromatosis Protein
MH  - Injections, Spinal/methods
MH  - Male
MH  - Membrane Proteins/*administration & dosage/therapeutic use
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Pain/*drug therapy
MH  - Pain Measurement/methods
MH  - Piperidines/pharmacology
MH  - Quinuclidines/pharmacology
MH  - Rats
MH  - Somatostatin/analogs & derivatives/pharmacology
MH  - Time Factors
EDAT- 2005/08/17 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/17 09:00
PHST- 2005/06/10 00:00 [received]
PHST- 2005/07/13 00:00 [revised]
PHST- 2005/07/13 00:00 [accepted]
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - S0006-8993(05)01067-X [pii]
AID - 10.1016/j.brainres.2005.07.020 [doi]
PST - ppublish
SO  - Brain Res. 2005 Sep 14;1056(1):51-8. doi: 10.1016/j.brainres.2005.07.020.