PMID- 16103458
OWN - NLM
STAT- MEDLINE
DCOM- 20051108
LR  - 20220311
IS  - 1055-9965 (Print)
IS  - 1055-9965 (Linking)
VI  - 14
IP  - 8
DP  - 2005 Aug
TI  - Positive and negative associations of human leukocyte antigen variants with the 
      onset and prognosis of adult glioblastoma multiforme.
PG  - 2040-4
AB  - Associations of genetic factors with malignant gliomas have been modest. We 
      examined the relationships of human leukocyte antigen (HLA) and related 
      polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic 
      Whites) from the San Francisco Bay area. For 155 glioblastoma multiforme patients 
      and 157 control subjects closely matched by ethnicity, age, and gender, PCR-based 
      techniques resolved alleles at HLA-A, -B, -C, and -DRB1 loci along with short 
      tandem repeat polymorphisms of MICA exon 5 and TNFb. By multivariable logistic 
      regression, B*13 and the B*07-Cw*07 haplotype were positively associated with 
      glioblastoma multiforme (P=0.01 and <0.001, respectively), whereas Cw*01 was the 
      only variant showing a negative association (P=0.05). Among glioblastoma 
      multiforme patients, progression to death after diagnosis was slower in those 
      with A*32 (relative hazard, 0.45; P<0.01) and faster in those with B*55 (relative 
      hazard, 2.27; P<0.01). Thus, both the occurrence and the prognosis of 
      glioblastoma multiforme could be associated with specific but different HLA 
      genotypes. B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians 
      than other ethnic groups in the U.S., which may partially explain the higher 
      incidence of glioblastoma multiforme in Caucasians.
FAU - Tang, Jianming
AU  - Tang J
AD  - Department of Medicine, University of Alabama at Birmingham, 1665 University 
      Boulevard, RPHB Room 220A, Birmingham, AL 35294-0022, USA.
FAU - Shao, Wenshuo
AU  - Shao W
FAU - Dorak, M Tevfik
AU  - Dorak MT
FAU - Li, Yufeng
AU  - Li Y
FAU - Miike, Rei
AU  - Miike R
FAU - Lobashevsky, Elena
AU  - Lobashevsky E
FAU - Wiencke, John K
AU  - Wiencke JK
FAU - Wrensch, Margaret
AU  - Wrensch M
FAU - Kaslow, Richard A
AU  - Kaslow RA
FAU - Cobbs, Charles S
AU  - Cobbs CS
LA  - eng
GR  - CA097247/CA/NCI NIH HHS/United States
GR  - CA097257/CA/NCI NIH HHS/United States
GR  - CA52689/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American 
      Association for Cancer Research, cosponsored by the American Society of 
      Preventive Oncology
JID - 9200608
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Glioblastoma/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Microsatellite Repeats
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - San Francisco
EDAT- 2005/08/17 09:00
MHDA- 2005/11/09 09:00
CRDT- 2005/08/17 09:00
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/11/09 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - 14/8/2040 [pii]
AID - 10.1158/1055-9965.EPI-05-0136 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2040-4. doi: 
      10.1158/1055-9965.EPI-05-0136.