PMID- 16103634
OWN - NLM
STAT- MEDLINE
DCOM- 20050913
LR  - 20091119
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 114
IP  - 2
DP  - 2005
TI  - A case of chronic myelomonocytic leukemia with severe eosinophilia having 
      t(5;12)(q31;p13) with t(1;7)(q10;p10).
PG  - 104-7
AB  - We describe an unusual case of chronic myelomonocytic leukemia with severe 
      eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10). The eosinophilic 
      proliferation was severe in peripheral blood and bone marrow, and they revealed 
      marked dysplastic features. We performed fluorescence in situ hybridization 
      (FISH) and immunohistochemistry to evaluate the clonality of eosinophils. The 
      eosinophils were stained positively to platelet-derived growth factor 
      receptor-beta. By FISH using chromosome 1 satellite probe and chromosome 1q 
      telomere probe, the eosinophils were proved to belong to the malignant clone.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Kim, Myungshin
AU  - Kim M
AD  - Department of Clinical Pathology, College of Medicine, Catholic University of 
      Korea, Seoul, Korea.
FAU - Lim, Jihyang
AU  - Lim J
FAU - Lee, Ahwon
AU  - Lee A
FAU - Park, Gyeongsin
AU  - Park G
FAU - Kim, Yonggoo
AU  - Kim Y
FAU - Han, Kyungja
AU  - Han K
FAU - Kang, Chang Suk
AU  - Kang CS
FAU - Kim, Yoo-Jin
AU  - Kim YJ
FAU - Song, Jeong-Sup
AU  - Song JS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor beta)
SB  - IM
MH  - Adolescent
MH  - Child, Preschool
MH  - Chromosomes, Human/*genetics
MH  - Eosinophilia/complications/genetics/metabolism/*pathology
MH  - Eosinophils/metabolism/*pathology
MH  - Humans
MH  - Leukemia, Myelomonocytic, Chronic/complications/genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Receptor, Platelet-Derived Growth Factor beta/biosynthesis
MH  - *Translocation, Genetic
EDAT- 2005/08/17 09:00
MHDA- 2005/09/15 09:00
CRDT- 2005/08/17 09:00
PHST- 2004/09/07 00:00 [received]
PHST- 2004/11/25 00:00 [accepted]
PHST- 2005/08/17 09:00 [pubmed]
PHST- 2005/09/15 09:00 [medline]
PHST- 2005/08/17 09:00 [entrez]
AID - 86584 [pii]
AID - 10.1159/000086584 [doi]
PST - ppublish
SO  - Acta Haematol. 2005;114(2):104-7. doi: 10.1159/000086584.