PMID- 16105260
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20190513
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 29
IP  - 5
DP  - 2005 Jul-Aug
TI  - The identification of a chlorinated MDMA.
PG  - 353-8
AB  - The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine 
      (MDMA) is increasing throughout the world. They have become popular drugs at all 
      night techno dance parties, and their detection is an important issue. The 
      objective of the presented study was to identify an unknown compound detected by 
      thin-layer chromatography (TLC) in the urine of an illicit drug abuser. The 
      compound was isolated by TLC and analyzed by gas chromatography-mass spectrometry 
      (GC-MS) in electron ionization (EI) and positive ion chemical ionization (PICI) 
      mode to elucidate its chemical structure. Based on EI-MS and PICI-MS mass 
      spectral data, the unknown compound was indicated to be a structure similar to 
      MDMA, substituted by a single chlorine atom-a chlorinated MDMA (Cl-MDMA). To 
      confirm the Cl-MDMA structure, the unknown compound was silylated, 
      trifluoroacetylated, acetylated, heptafluorobutyrylated, and analyzed by GC-MS. 
      The position of the chlorine atom cannot be assigned exactly from the mass 
      spectral data presented here; however, we believe that the unknown compound could 
      be 6-Cl-MDMA.
FAU - Maresova, V
AU  - Maresova V
AD  - Institute of Forensic Medicine and Toxicology, First Medical Faculty and 
      Hospital, Charles University of Prague, Czech Republic.
FAU - Hampl, J
AU  - Hampl J
FAU - Chundela, Z
AU  - Chundela Z
FAU - Zrcek, F
AU  - Zrcek F
FAU - Polasek, M
AU  - Polasek M
FAU - Chadt, J
AU  - Chadt J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Designer Drugs)
RN  - 0 (Hallucinogens)
RN  - 4R7X1O2820 (Chlorine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Chlorine/*chemistry
MH  - Chromatography, Thin Layer
MH  - Designer Drugs/*chemistry
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hallucinogens/*chemistry/urine
MH  - Humans
MH  - Male
MH  - Molecular Structure
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*chemistry/urine
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - *Substance Abuse Detection
EDAT- 2005/08/18 09:00
MHDA- 2006/09/23 09:00
CRDT- 2005/08/18 09:00
PHST- 2005/08/18 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2005/08/18 09:00 [entrez]
AID - 10.1093/jat/29.5.353 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2005 Jul-Aug;29(5):353-8. doi: 10.1093/jat/29.5.353.