PMID- 16105263
OWN - NLM
STAT- MEDLINE
DCOM- 20060922
LR  - 20190513
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 29
IP  - 5
DP  - 2005 Jul-Aug
TI  - Gas chromatography-high-resolution mass spectrometric method for determination of 
      methamphetamine and its major metabolite amphetamine in human hair.
PG  - 370-5
AB  - Gas chromatography-high-resolution mass spectrometric (GC-HRMS) method is 
      presented for the qualitative and quantitative analysis of methamphetamine (MA) 
      and its major metabolite, amphetamine (AMP), in human hair. The method procedure 
      involves decontamination of hair with distilled water and acetone, acidic 
      hydrolysis and extraction in the presence of the internal standard, and GC-HRMS 
      selective ion monitoring (SIM) analysis. The limits of detection (LOD) were 9 
      pg/mg for MA and 21 pg/mg for AMP using a 30-mg hair sample, and the SIM 
      responses were linear with coefficients of correlation ranged from 0.9998 to 
      0.9999. The recoveries were found to be 91.1-92.3%. By using HRMS (resolution of 
      5000), detection sensitivity is improved because of the elimination of the 
      biological background, and the LODs for MA and AMP were 2.4-4.4 times lower than 
      those of low-resolution MS. The GC-HRMS method was successfully applied to the 
      analysis of cosmetically treated hair, which is difficult to analyze with the 
      conventional method.
FAU - Kim, Jin Young
AU  - Kim JY
AD  - Drug Analysis Laboratory, Supreme Prosecutors' Office, Seoul, Korea.
FAU - Suh, Sung Ill
AU  - Suh SI
FAU - In, Moon Kyo
AU  - In MK
FAU - Chung, Bong Chul
AU  - Chung BC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Hair Preparations)
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*analysis
MH  - Decontamination
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Hair Preparations
MH  - Humans
MH  - Methamphetamine/*analysis
MH  - Reproducibility of Results
MH  - *Substance Abuse Detection
EDAT- 2005/08/18 09:00
MHDA- 2006/09/23 09:00
CRDT- 2005/08/18 09:00
PHST- 2005/08/18 09:00 [pubmed]
PHST- 2006/09/23 09:00 [medline]
PHST- 2005/08/18 09:00 [entrez]
AID - 10.1093/jat/29.5.370 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2005 Jul-Aug;29(5):370-5. doi: 10.1093/jat/29.5.370.