PMID- 16109069
OWN - NLM
STAT- MEDLINE
DCOM- 20051007
LR  - 20181113
IS  - 1399-543X (Print)
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 6
IP  - 3
DP  - 2005 Sep
TI  - Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes 
      risk estimates.
PG  - 136-44
AB  - OBJECTIVE: Certain human leukocyte antigen (HLA)-DR,DQ genotypes have been 
      associated with type 1 diabetes mellitus (T1DM) risk, although it is unknown 
      whether the association is due to alleles, haplotypes, genotypes, the formation 
      of heterodimers, or all of the above. To characterize the role of the HLA-DR,DQ 
      genotype and ethnicity on the onset age of T1DM, we analyzed these factors in 
      patients with T1DM and the general population. METHODS: One thousand three 
      hundred twenty-two well-characterized patients with T1DM were compared with 3339 
      children from the general population of Denver, Colorado, USA. Because of the 
      extensive available data across age and ethnic groups, this study population is 
      unique. RESULTS: The HLA-DR3/4,DQB1*0302, DRX/4,DQB1*0302 (where X=1, 4, 8, and 
      9), and HLA--DR3/3 genotypes were associated with T1DM, supporting previous 
      research. Additionally, the DR3/9 genotype showed a positive association with 
      T1DM, which has not previously been described in Caucasian populations. The 
      HLA-DR3/4*0302 genotype was most strongly associated with T1DM in diabetic 
      individuals with the youngest onset age. Genotype frequencies were similar 
      between Hispanics and non-Hispanic whites, except for the DR3/3 genotype, which 
      was more likely to be found in non-Hispanic whites. CONCLUSIONS: These results 
      indicate that there are multiple alleles and genotypes associated with T1DM and 
      that the risk associated with different genetic markers depends on the age of 
      disease onset, suggesting that some markers may be involved in more rapid disease 
      progression.
FAU - Emery, Lisa M
AU  - Emery LM
AD  - Department of Preventive Medicine and Biometrics, University of Colorado Health 
      Sciences Center, Denver, CO, USA.
FAU - Babu, Sunanda
AU  - Babu S
FAU - Bugawan, Teodorica L
AU  - Bugawan TL
FAU - Norris, Jill M
AU  - Norris JM
FAU - Erlich, Henry A
AU  - Erlich HA
FAU - Eisenbarth, George S
AU  - Eisenbarth GS
FAU - Rewers, Marian
AU  - Rewers M
LA  - eng
GR  - P30 DK057516/DK/NIDDK NIH HHS/United States
GR  - R01-DK57516/DK/NIDDK NIH HHS/United States
GR  - R01 DK032083/DK/NIDDK NIH HHS/United States
GR  - R01-DK32493/DK/NIDDK NIH HHS/United States
GR  - R37 DK032493/DK/NIDDK NIH HHS/United States
GR  - R01 DK050979/DK/NIDDK NIH HHS/United States
GR  - R01-DK32083/DK/NIDDK NIH HHS/United States
GR  - R01 DK032493/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Age of Onset
MH  - Diabetes Mellitus, Type 1/ethnology/*genetics
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - *HLA-DQ Antigens
MH  - *HLA-DR Antigens
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Risk Factors
PMC - PMC1351310
MID - NIHMS4756
EDAT- 2005/08/20 09:00
MHDA- 2005/10/08 09:00
PMCR- 2008/01/24
CRDT- 2005/08/20 09:00
PHST- 2005/08/20 09:00 [pubmed]
PHST- 2005/10/08 09:00 [medline]
PHST- 2005/08/20 09:00 [entrez]
PHST- 2008/01/24 00:00 [pmc-release]
AID - PDI117 [pii]
AID - 10.1111/j.1399-543X.2005.00117.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2005 Sep;6(3):136-44. doi: 10.1111/j.1399-543X.2005.00117.x.