PMID- 16109607
OWN - NLM
STAT- MEDLINE
DCOM- 20050928
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 46
IP  - 9
DP  - 2005 Sep
TI  - The prognostic value of the expression of Bcl-2, p53 and LMP-1 in patients with 
      Hodgkin's lymphoma.
PG  - 1301-6
AB  - This study was undertaken to evaluate the clinical significance of the expression 
      of Bcl-2, p53 and LMP-1 in Hodgkin and Reed - Sternberg cells of patients with 
      Hodgkin's lymphoma. The expression of these proteins in pre-treatment tissue 
      biopsy specimens was correlated with presenting clinical features, failure-free 
      survival (FFS) and overall survival (OS) in 83 patients with a confirmed 
      Hodgkin's lymphoma treated in a single institution. HIV-positive patients were 
      excluded. Patients were classified according to the International Prognostic 
      Score (IPS) in low-risk (0 - 2 factors) and high-risk groups. The median age was 
      41 years (15 - 84), 41% were women, and 93% had advanced-stage disease (IIB - 
      IVB). The expression of Bcl-2, p53 and LMP-1 was not associated with the complete 
      remission rate, FFS or OS. The IPS risk group was the only factor significantly 
      associated with OS. Patients with a high IPS had a lower 5 year OS (43% vs. 79%, 
      P = 0.003). The expression of Bcl-2, p53 and LMP-1 did not add prognostic 
      information to the IPS.
FAU - Spector, Nelson
AU  - Spector N
AD  - Hematology Service, School of Medicine and University Hospital, Federal 
      University of Rio de Janeiro, Rio de Janeiro, Brazil. spector@ufri.br
FAU - Milito, Cristiane Bedran
AU  - Milito CB
FAU - Biasoli, Irene
AU  - Biasoli I
FAU - Luiz, Ronir Raggio
AU  - Luiz RR
FAU - Pulcheri, Wolmar
AU  - Pulcheri W
FAU - Morais, Jose Carlos
AU  - Morais JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (PDLIM7 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cytoskeletal Proteins
MH  - Female
MH  - Gene Expression
MH  - *Genes, p53
MH  - Hodgkin Disease/*genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - LIM Domain Proteins
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-bcl-2/*genetics
EDAT- 2005/08/20 09:00
MHDA- 2005/09/29 09:00
CRDT- 2005/08/20 09:00
PHST- 2005/08/20 09:00 [pubmed]
PHST- 2005/09/29 09:00 [medline]
PHST- 2005/08/20 09:00 [entrez]
AID - WV16N5G875N77H5H [pii]
AID - 10.1080/10428190500126034 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2005 Sep;46(9):1301-6. doi: 10.1080/10428190500126034.