PMID- 16110810
OWN - NLM
STAT- MEDLINE
DCOM- 20051007
LR  - 20190513
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 43 Suppl 1
DP  - 2005 May
TI  - Immunity to Aspergillus fumigatus: the basis for immunotherapy and vaccination.
PG  - S181-8
AB  - Efficient responses to fungi require different mechanisms of immunity. Dendritic 
      cells (DCs) are uniquely able to decode the fungus-associated information and 
      translate it into qualitatively different T helper (Th) immune responses. Murine 
      and human DCs phagocytose conidia and hyphae of Aspergillus fumigatus through 
      distinct recognition receptors. The engagement of distinct receptors translates 
      into disparate downstream signaling events, ultimately affecting cytokine 
      production and co-stimulation. Adoptive transfer of different types of DCs 
      activates protective and non-protective Th cells as well as regulatory T cells, 
      ultimately affecting the outcome of the infection in mice with invasive 
      aspergillosis. The infusion of fungus-pulsed or RNA-transfected DCs also 
      accelerates recovery of functional antifungal Th 1 responses in mice with 
      allogeneic hematopoietic stem cell transplantation. Patients receiving T 
      cell-depleted allogeneic hematopoietic stem cell transplantation are unable to 
      develop antigen-specific T cell responses soon after transplant due to defective 
      DC functions. Our results suggest that the adoptive transfer of DCs may restore 
      immunocompetence in hematopoietic stem cell transplantation by contributing to 
      the educational program of T cells. Thus, the remarkable furictional plasticity 
      of DCs can be exploited for the deliberate targeting of cells and pathways of 
      cell-mediated immunity in response to the fungus.
FAU - Bellocchio, S
AU  - Bellocchio S
AD  - Microbiology Section, Department of Experimental Medicine and Biochemical 
      Sciences, University of Perugia, Perugia, Italy.
FAU - Bozza, S
AU  - Bozza S
FAU - Montagnoli, C
AU  - Montagnoli C
FAU - Perruccio, K
AU  - Perruccio K
FAU - Gaziano, R
AU  - Gaziano R
FAU - Pitzurra, L
AU  - Pitzurra L
FAU - Romani, L
AU  - Romani L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Aspergillosis/*immunology/microbiology/*therapy
MH  - Aspergillus fumigatus/*immunology/pathogenicity
MH  - Dendritic Cells/*immunology/*transplantation
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunotherapy
MH  - Mice
MH  - Vaccination
RF  - 77
EDAT- 2005/08/23 09:00
MHDA- 2005/10/08 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/10/08 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - 10.1080/14789940500051417 [doi]
PST - ppublish
SO  - Med Mycol. 2005 May;43 Suppl 1:S181-8. doi: 10.1080/14789940500051417.