PMID- 16110833
OWN - NLM
STAT- MEDLINE
DCOM- 20050908
LR  - 20190721
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 50
IP  - 8
DP  - 2005 Aug
TI  - Effect of bacterial chemotactic peptides on intestinal inflammation in animal 
      models of acute and chronic "relapsed" colitis.
PG  - 1444-53
AB  - It is known that bacterial chemotactic peptides such as 
      formyl-methionyl-leucyl-phenylalanine (fMLP) exacerbate colitis during the acute 
      phase, but the precise role of fMLP during chronic "relapse" is unknown. In this 
      study we examined the effect of bacterial peptides in animal models of acute and 
      chronic "relapsed" colitis. Different parameters were evaluated, such as tissue 
      damage, myeloperoxidase activity, and mucosal function. In acute trinitrobenezene 
      sulfonic acid colitis, fMLP had significant adverse effects on mucosal function 
      and worsened several parameters. In contrast, in chronic "relapsed" colitis the 
      ability of fMLP to exacerbate the inflammation was dependent on whether it was 
      confined to the lumen of the colon. Bacterial peptides such as fMLP appear to 
      play a different role in the acute phase of inflammation compared with the 
      chronic phase, depending on the integrity of the mucosal barrier.
FAU - Hernandez, Gerardo A
AU  - Hernandez GA
AD  - Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 
      00732-7004.
FAU - Valentin, Melanie R
AU  - Valentin MR
FAU - Appleyard, Caroline B
AU  - Appleyard CB
LA  - eng
GR  - 2G12RR03050/RR/NCRR NIH HHS/United States
GR  - S06 GM008239/GM/NIGMS NIH HHS/United States
GR  - F31DK60245/DK/NIDDK NIH HHS/United States
GR  - F31 DK060245/DK/NIDDK NIH HHS/United States
GR  - G12 RR003050/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Bacterial Proteins)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Bacterial Proteins/*pharmacology
MH  - Chronic Disease
MH  - Colitis/etiology/*metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Gastric Mucosa/*drug effects/metabolism/physiopathology
MH  - Male
MH  - N-Formylmethionine Leucyl-Phenylalanine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recurrence
EDAT- 2005/08/23 09:00
MHDA- 2005/09/09 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/09/09 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - 10.1007/s10620-005-2859-3 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2005 Aug;50(8):1444-53. doi: 10.1007/s10620-005-2859-3.