PMID- 16111007
OWN - NLM
STAT- MEDLINE
DCOM- 20051202
LR  - 20190917
IS  - 0730-7268 (Print)
IS  - 0730-7268 (Linking)
VI  - 24
IP  - 5
DP  - 2005 May
TI  - Association between lymphocyte proliferation and polychlorinated biphenyls in 
      free-ranging harbor seal (Phoca vitulina) pups from British Columbia, Canada.
PG  - 1247-52
AB  - Recent pinniped die-offs have led to the speculation that persistent organic 
      pollutants (POPs) are immunomodulatory, making individuals more susceptible to 
      viral infections. Eighteen healthy harbor seal (Phoca vitulina) pups (aged 3-4 
      weeks) were live-captured from southern British Columbia, Canada, and maintained 
      temporarily in captivity for an immunotoxicological assessment. The relationships 
      between mitogen-induced peripheral blood lymphocyte proliferation and blubber 
      concentrations of three major immunotoxic POP classes (the polychlorinated 
      biphenyls [PCBs], polychlorinated dibenzo-p-dioxins [PCDDs], and the 
      polychlorinated dibenzofurans [PCDFs]) were evaluated. A significant body 
      weight-independent positive correlation was observed between both T-cell mitogen 
      (phytohemagglutinin [PHA])- and B-cell mitogen (lipopolysaccharide [LPS])-induced 
      lymphocyte proliferation and the blubber concentrations of total PCB. Best subset 
      regression analysis revealed that total PCBs, and not total PCDD or total PCDF, 
      explained 24 and 29% of the changes in both T-cell mitogen-and B-cell 
      mitogen-induced lymphocyte proliferation, respectively. Further regression 
      analysis performed on the PCB classes measured in this study showed that di-ortho 
      PCBs accounted for 25 and 30% of the changes in both T-cell and B-cell lymphocyte 
      proliferation, respectively. Results suggest that POPs, and PCBs in particular, 
      are associated with changes in lymphocyte proliferation, something that could 
      result in increased susceptibility to infections in harbor seal pups. Further 
      research is needed to evaluate the relative roles of natural and 
      contaminant-related influences on the immune system of marine mammals.
FAU - Levin, Milton
AU  - Levin M
AD  - Department of Pathobiology and Veterinary Science, University of Connecticut, 61 
      North Eagleville Road, U-89, Storrs, Connecticut 06269, USA. 
      milton.levin@uconn.edu
FAU - De Guise, Sylvain
AU  - De Guise S
FAU - Ross, Peter S
AU  - Ross PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*drug effects/metabolism
MH  - British Columbia
MH  - Phoca/*immunology
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Regression Analysis
MH  - Risk Assessment
MH  - T-Lymphocytes/*drug effects/metabolism
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2005/08/23 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - 10.1897/04-206r.1 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2005 May;24(5):1247-52. doi: 10.1897/04-206r.1.