PMID- 16111804
OWN - NLM
STAT- MEDLINE
DCOM- 20060809
LR  - 20081121
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 238
IP  - 2
DP  - 2006 Jul 18
TI  - Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell 
      carcinoma.
PG  - 224-9
AB  - The gene for insulin-like growth factor two, IGF2 is maternally imprinted. 
      Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and 
      promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six 
      laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of 
      specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 
      promoter usage was active in eight LSCCs, among them four with LOI. As it was 
      activated in four tumors with maintenance of imprinting (MOI) and four 
      non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 
      LOI in LSCC.
FAU - Grbesa, Ivana
AU  - Grbesa I
AD  - Laboratory of Molecular Pathology, Division of Molecular Medicine, Rudjer 
      Boskovic Institute, Bijenicka cesta 54, 10002 Zagreb, Croatia. troselj@irb.hr
FAU - Ivkic, Mirko
AU  - Ivkic M
FAU - Pegan, Boris
AU  - Pegan B
FAU - Gall-Troselj, Koraljka
AU  - Gall-Troselj K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050818
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics
MH  - *Genomic Imprinting
MH  - Humans
MH  - Insulin-Like Growth Factor II/*genetics
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Promoter Regions, Genetic
EDAT- 2005/08/23 09:00
MHDA- 2006/08/10 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/05/09 00:00 [received]
PHST- 2005/07/07 00:00 [revised]
PHST- 2005/07/08 00:00 [accepted]
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2006/08/10 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - S0304-3835(05)00659-2 [pii]
AID - 10.1016/j.canlet.2005.07.003 [doi]
PST - ppublish
SO  - Cancer Lett. 2006 Jul 18;238(2):224-9. doi: 10.1016/j.canlet.2005.07.003. Epub 
      2005 Aug 18.