PMID- 16112415
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20131121
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 227
IP  - 2
DP  - 2005 Sep 28
TI  - Protective effects of black tea extract on testosterone induced oxidative damage 
      in prostate.
PG  - 125-32
AB  - Since ancient times, antipyretic, anti-inflammatory, antimicrobial and 
      antioxidative properties of tea have been recognized. Black tea (Camellia 
      sinensis) contains a variety of polyphenolic ingredients including the 
      theaflavins (TF), thearubigins (TG) and catechins. Components from black tea have 
      been accounted to play an important role in scavenging free radicals generated by 
      mutagens and carcinogens. Androgens are the key factors in either the initiation 
      or progression of prostate cancer (PCA) by inducing oxidative stress. In the 
      present set of investigations, the antioxidative potential of black tea extract 
      against androgen mediated oxidative stress in male Wistar rats has been studied. 
      Testosterone was given at a dose of 5 mg/kg b.w. subcutaneously, consecutively 
      for 5 days. Prior to androgen administration, animals were kept on 0.5, 1.0 and 
      1.5% aqueous tea extract (ATE) as sole source of drinking fluid for 15 days. The 
      prostate tissue was dissected out for biochemical analysis for antioxidant 
      enzymes viz. catalase (CAT), superoxide dismutase (SOD), lipid peroxidation 
      (LPO), glutathione-s-transferase (GST) and glutathione reductase (GR). The 
      results revealed that testosterone administration induced the oxidative stress in 
      rat prostate, however, in 0.5, 1.0 and 1.5% ATE supplemented groups, a 
      significant protective effect of black tea against testosterone induced oxidative 
      injury was recorded. Hence, the study reveals that constituents present in black 
      tea impart protection against androgen induced oxidative injury that may result 
      in development of prostate cancer.
FAU - Siddiqui, Imtiaz A
AU  - Siddiqui IA
AD  - Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, 
      M.G. Marg, P.O. Box 80, Lucknow 226 001, India.
FAU - Raisuddin, S
AU  - Raisuddin S
FAU - Shukla, Yogeshwer
AU  - Shukla Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Tea)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - *Antioxidants
MH  - Catalase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Injections, Subcutaneous
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Plant Extracts/*therapeutic use
MH  - Prostate/drug effects
MH  - Prostatic Neoplasms/metabolism/*prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - *Tea
MH  - Testosterone/*pharmacology
EDAT- 2005/08/23 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/08/23 09:00
PHST- 2004/08/10 00:00 [received]
PHST- 2004/09/20 00:00 [revised]
PHST- 2004/10/20 00:00 [accepted]
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - S0304-3835(04)00855-9 [pii]
AID - 10.1016/j.canlet.2004.10.046 [doi]
PST - ppublish
SO  - Cancer Lett. 2005 Sep 28;227(2):125-32. doi: 10.1016/j.canlet.2004.10.046.