PMID- 16112654 OWN - NLM STAT- MEDLINE DCOM- 20051130 LR - 20220316 IS - 0006-3223 (Print) IS - 0006-3223 (Linking) VI - 58 IP - 7 DP - 2005 Oct 1 TI - Psychopathology in the offspring of parents with bipolar disorder: a controlled study. PG - 554-61 AB - BACKGROUND: To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth. METHODS: Using structured diagnostic interviews (Structured Clinical Interview for DSM-IV [SCID] and Kiddie Schedule for Affective Disorders and Schizophrenia [K-SADS]), psychiatric diagnoses of 117 nonreferred offspring of parents with diagnosed bipolar disorder were compared with those of 171 age- and gender-matched offspring of parents without bipolar disorder or major depression. RESULTS: Compared with offspring of parents without mood disorders, high-risk youth had elevated rates of major depression and bipolar disorder, anxiety, and disruptive behavior disorders. High-risk offspring also had significantly more impaired Global Assessment of Functioning (GAF) scores, higher rates of psychiatric treatment, and higher rates of placement in special education classes. Disruptive behavior disorders, separation anxiety disorder, generalized anxiety disorder (GAD), social phobia, and depression tended to have their onset in early or middle childhood, whereas bipolar disorder, obsessive-compulsive disorder (OCD), panic disorder, and substance use disorder had onset most frequently in adolescence. CONCLUSIONS: These findings support the hypothesis that offspring of parents with bipolar disorder are at significantly increased risk for developing a wide range of severe psychiatric disorders and accompanying dysfunction. Early disruptive behavior and anxiety disorders, as well as early-onset depression, may be useful markers of risk for subsequent bipolar disorder in high-risk samples. FAU - Henin, Aude AU - Henin A AD - Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA. ahenin@partners.org FAU - Biederman, Joseph AU - Biederman J FAU - Mick, Eric AU - Mick E FAU - Sachs, Gary S AU - Sachs GS FAU - Hirshfeld-Becker, Dina R AU - Hirshfeld-Becker DR FAU - Siegel, Rebecca S AU - Siegel RS FAU - McMurrich, Stephanie AU - McMurrich S FAU - Grandin, Louisa AU - Grandin L FAU - Nierenberg, Andrew A AU - Nierenberg AA LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20050822 PL - United States TA - Biol Psychiatry JT - Biological psychiatry JID - 0213264 SB - IM MH - Adolescent MH - Adult MH - Age of Onset MH - Anxiety Disorders/epidemiology/psychology MH - Attention Deficit and Disruptive Behavior Disorders/epidemiology/psychology MH - Bipolar Disorder/*psychology MH - Child MH - Child Behavior Disorders/*epidemiology/*psychology MH - Family MH - Female MH - Humans MH - Male MH - Middle Aged MH - Mood Disorders/epidemiology/psychology MH - Psychiatric Status Rating Scales MH - Psychopathology MH - Risk Factors MH - Social Behavior EDAT- 2005/08/23 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/08/23 09:00 PHST- 2004/12/13 00:00 [received] PHST- 2005/04/05 00:00 [revised] PHST- 2005/06/07 00:00 [accepted] PHST- 2005/08/23 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/08/23 09:00 [entrez] AID - S0006-3223(05)00716-X [pii] AID - 10.1016/j.biopsych.2005.06.010 [doi] PST - ppublish SO - Biol Psychiatry. 2005 Oct 1;58(7):554-61. doi: 10.1016/j.biopsych.2005.06.010. Epub 2005 Aug 22.