PMID- 16112901
OWN - NLM
STAT- MEDLINE
DCOM- 20051109
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 116
IP  - 10
DP  - 2005 Oct
TI  - All-night EEG power spectral analysis of the cyclic alternating pattern 
      components in young adult subjects.
PG  - 2429-40
AB  - OBJECTIVE: To analyze in detail the frequency content of the different EEG 
      components of the Cyclic Alternating Pattern (CAP), taking into account the 
      ongoing EEG background and the nonCAP (NCAP) periods in the whole night 
      polysomnographic recordings of normal young adults. METHODS: Sixteen normal 
      healthy subjects were included in this study. Each subject underwent one 
      polysomnographic night recording; sleep stages were scored following standard 
      criteria. Subsequently, each CAP A phase was detected in all recordings, during 
      NREM sleep, and classified into 3 subtypes (A1, A2, and A3). The same channel 
      used for the detection of CAP A phases (C3/A2 or C4/A1) was subdivided into 2-s 
      mini-epochs. For each mini-epoch, the corresponding CAP condition was determined 
      and power spectra calculated in the frequency range 0.5-25 Hz. Average spectra 
      were obtained for each CAP condition, separately in sleep stage 2 and SWS, for 
      each subject. Finally, the first 6h of sleep were subdivided into 4 periods of 90 
      min each and the same spectral analysis was performed for each period. RESULTS: 
      During sleep stage 2, CAP A subtypes differed from NCAP periods for all frequency 
      bins between 0.5 and 25 Hz; this difference was most evident for the lowest 
      frequencies. The B phase following A1 subtypes had a power spectrum significantly 
      higher than that of NCAP, for frequencies between 1 and 11 Hz. The B phase after 
      A2 only differed from NCAP for a small but significant reduction in the sigma 
      band power; this was evident also after A3 subtypes. During SWS, we found similar 
      results. The comparison between the different CAP subtypes also disclosed 
      significant differences related to the stage in which they occurred. Finally, a 
      significant effect of the different sleep periods was found on the different CAP 
      subtypes during sleep stage 2 and on NCAP in both sleep stage 2 and SWS. 
      CONCLUSIONS: CAP subtypes are characterized by clearly different spectra and also 
      the same subtype shows a different power spectrum, during sleep stage 2 or SWS. 
      This finding underlines a probable different functional meaning of the same CAP 
      subtype during different sleep stages. We also found 3 clear peaks of difference 
      between CAP subtypes and NCAP in the delta, alpha, and beta frequency ranges 
      which might indicate the presence of 3 frequency components characterizing CAP 
      subtypes, in different proportion in each of them. The B component of CAP differs 
      from NCAP because of a decrease in power in the sigma frequency range. 
      SIGNIFICANCE: This study shows that A components of CAP might correspond to 
      periods in which the very-slow delta activity of sleep groups a range of 
      different EEG activities, including the sigma and beta bands, while the B phase 
      of CAP might correspond to a period in which this activity is quiescent or 
      inhibited.
FAU - Ferri, Raffaele
AU  - Ferri R
AD  - Department of Neurology IC, Sleep Research Centre, Oasi Institute (IRCCS), Via 
      Conte Ruggero 73, 94018 Troina, Italy. rferri@oasi.en.it
FAU - Bruni, Oliviero
AU  - Bruni O
FAU - Miano, Silvia
AU  - Miano S
FAU - Plazzi, Giuseppe
AU  - Plazzi G
FAU - Terzano, Mario G
AU  - Terzano MG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Data Interpretation, Statistical
MH  - *Electroencephalography
MH  - Electromyography
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polysomnography
MH  - Reference Values
MH  - Sleep
MH  - Sleep Stages/*physiology
MH  - Sleep, REM/physiology
MH  - Software
EDAT- 2005/08/23 09:00
MHDA- 2005/11/10 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/02/24 00:00 [received]
PHST- 2005/05/23 00:00 [revised]
PHST- 2005/06/20 00:00 [accepted]
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/11/10 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - S1388-2457(05)00269-5 [pii]
AID - 10.1016/j.clinph.2005.06.022 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2005 Oct;116(10):2429-40. doi: 10.1016/j.clinph.2005.06.022.