PMID- 16113751
OWN - NLM
STAT- MEDLINE
DCOM- 20051004
LR  - 20191109
IS  - 0720-9355 (Print)
IS  - 0720-9355 (Linking)
VI  - 25
IP  - 3
DP  - 2005 Aug
TI  - [Monitoring of the heparin therapy during acute haemodialysis].
PG  - 272-8; quiz 279-80
AB  - Anticoagulation during renal replacement therapy is recommended to avoid 
      thrombosis of the filter devices and to maintain the blood flow. However, in the 
      case of multiorgan failure and sepsis, an imminent bleeding complication in 
      patients with acute renal failure may cause the need for an extracorporeal 
      circulation without anticoagulation. The most common drug used in renal 
      replacement therapy is the unfractionated heparin (UFH). With low molecular 
      weight heparin (LMWH) good experiences are reported, too. Based on the level of 
      evidence from clinical studies plasma measurement of heparin is indispensable for 
      patients with renal insufficiency. The activated whole blood clotting time (ACT), 
      the activated partial thromboplastin time (aPTT), and the determination of the 
      anti-factor Xa activity (anti Xa) with chromogenic substrates are available as 
      routine as well as as point-of-care tests. To monitor plasma levels of LMWH the 
      anti Xa assay serves exclusively as a suitable monitoring. The anti Xa assay 
      using chromogenic substrates is the most specific and valid one for monitoring 
      heparin therapy. In lack of large controlled studies for the anticoagulation 
      therapy and its monitoring with the anti Xa test in acute renal failure, the 
      current experiences are based on the results of chronic renal replacement 
      therapy.
FAU - Molitor, B
AU  - Molitor B
AD  - Zentrum fur Labormedizin und Mikrobiologie GmbH, Herwarthstr. 100, 45138 Essen.
FAU - Klingel, R
AU  - Klingel R
FAU - Hafner, G
AU  - Hafner G
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Uberwachung der Heparintherapie bei Akutdialysen.
PL  - Germany
TA  - Hamostaseologie
JT  - Hamostaseologie
JID - 8204531
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Drug Monitoring
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Kidney Failure, Chronic/therapy
MH  - Renal Dialysis/*methods
RF  - 74
EDAT- 2005/08/23 09:00
MHDA- 2005/10/05 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/10/05 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - 05030272 [pii]
AID - 10.1267/hamo05030272 [doi]
PST - ppublish
SO  - Hamostaseologie. 2005 Aug;25(3):272-8; quiz 279-80. doi: 10.1267/hamo05030272.