PMID- 16113792
OWN - NLM
STAT- MEDLINE
DCOM- 20050915
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 94
IP  - 1
DP  - 2005 Jul
TI  - Increased prevalence of factor V Leiden in patients with retinal vein occlusion 
      and under 60 years of age.
PG  - 101-6
AB  - Retinal vein occlusion (RVO) is a multifactorial disease involving vessel damage, 
      stasis, viscosity and thrombosis. Conflicting findings on hereditary 
      thrombophilic risk factors have been reported and their impact on RVO features 
      remains to be defined. The aim of the present study was to evaluate the 
      prevalence of hereditary thrombophilic risk factors (HTRF) and characteristics of 
      RVO in patients with or without HTRF. The design of the study was a prospective, 
      observational case series. Two hundred and thirty-four patients with RVO were 
      included consecutively. A French healthy population of the same region was 
      studied as control group. The HTRF studied were protein C (PC), protein S (PS) 
      and antithrombin (AT) deficiencies, factor V Leiden (FVL) and factor II 20210A 
      polymorphisms. Chi-Square was used for comparison with the healthy subjects and 
      between RVO patient with and without HTRF according to localisation (branch vs. 
      central), type of RVO (ischemic or non-ischemic), recurrence, age at first event 
      and classical vascular risk factors. Twenty-two patients had HTRF (12 FV Leiden 
      heterozygotes, 9 FII 20210A heterozygotes and 1 PS deficiency). No AT or PC 
      deficiency was detected. Frequencies of PS deficiency, FVL and FII 20210A allele 
      were similar to the reference population as well as to published data in the 
      general caucasian population. Eighty-six patients experienced their first episode 
      before the age of 60 years. Systemic hypertension, glaucoma and angina were 
      significantly less frequent in patients with RVO before 60 years. Fourteen of the 
      22 patients with one HTRF (64%) experienced their first episode of RVO before the 
      age of 60 years compared to 72 of 212 without HTRF (34%) (p = 0.006). 
      Heterozygote status for FV Leiden was significantly more frequent in patients who 
      had experienced their first episode of RVO before 60 years (p = 0.027). In 
      conclusion, this study suggests a role of FV Leiden in the occurrence of RVO in 
      patients younger than 60 years who exhibit fewer acquired vascular risk factors 
      than in older patients.
FAU - Arsene, Sophie
AU  - Arsene S
AD  - Laboratoire d'Hemostase, Hopital Trousseau, CHU de Tours, 37044 Tours Cedex 1, 
      France.
FAU - Delahousse, Benedicte
AU  - Delahousse B
FAU - Regina, Sandra
AU  - Regina S
FAU - Le Lez, Marie-Laure
AU  - Le Lez ML
FAU - Pisella, Pierre-Jean
AU  - Pisella PJ
FAU - Gruel, Yves
AU  - Gruel Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Antithrombins)
RN  - 0 (Protein C)
RN  - 0 (Protein S)
RN  - 0 (factor V Leiden)
RN  - 9001-24-5 (Factor V)
RN  - 9001-26-7 (Prothrombin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Antithrombins/biosynthesis
MH  - Factor V/biosynthesis/*genetics
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Protein C/biosynthesis
MH  - Protein S/biosynthesis
MH  - Prothrombin/biosynthesis
MH  - Retinal Vein Occlusion/epidemiology/*genetics
MH  - Risk Factors
MH  - Thrombophilia/epidemiology/genetics
MH  - Thrombosis
MH  - Time Factors
EDAT- 2005/08/23 09:00
MHDA- 2005/09/16 09:00
CRDT- 2005/08/23 09:00
PHST- 2005/08/23 09:00 [pubmed]
PHST- 2005/09/16 09:00 [medline]
PHST- 2005/08/23 09:00 [entrez]
AID - 05070101 [pii]
AID - 10.1160/TH04-10-0659 [doi]
PST - ppublish
SO  - Thromb Haemost. 2005 Jul;94(1):101-6. doi: 10.1160/TH04-10-0659.