PMID- 16115149
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20191210
IS  - 0896-4327 (Print)
IS  - 0896-4327 (Linking)
VI  - 18
IP  - 4
DP  - 2005 Aug
TI  - The impact of age in the immediate and long-term outcomes of percutaneous mitral 
      balloon valvuloplasty.
PG  - 217-25
AB  - BACKGROUND: Differences in age, clinical characteristics, and valve morphology 
      may account for controversial results of percutaneous mitral balloon 
      valvuloplasty (PMV). METHODS: We have previously reported the immediate and 
      long-term clinical follow-up (50 +/- 45 months) of 879 patients who underwent PMV 
      at the Massachusetts General Hospital. In the present study, we used this 
      database to determine the impact of age in the immediate and long-term outcome of 
      PMV. For purpose of analysis, these patients were divided into four age groups: 
      group 1 (< or =35 years), group 2 (36-55 years), group 3 (56-75 years), and group 
      4 (>75 years). RESULTS: The incidence of atrial fibrillation, calcified valves 
      under fluoroscopy, higher echocardiographic score, New York Heart Association 
      (NYHA) class IV and pre-PMV mitral regurgitation (MR) increased with patient's 
      age. As patients became older, a lower post-PMV mitral valve area (2.1 +/- 0.7, 
      2.0 +/- 0.6, 1.8 +/- 0.6, and 1.6 +/- 0.6; P < 0.0001) and progressive decrease 
      in procedural success (81.4%, 80.5%, 65.3%, and 53%; P < 0.0001) were observed. 
      Younger age was identified as an independent predictor of PMV success by multiple 
      stepwise logistic regression (odds ratio [OR]: 3.33; confidence interval [CI]: 
      1.41-7.69, P = 0.006). Furthermore, age was identified as an independent 
      predictor of long-term events by Cox regression analysis (risk ratio [RR]: 1.02; 
      CI: 1.01-1.03, P < 0.00001). However, the effect of age seemed to be blunted by 
      the morphology of the valve at follow-up, as patients with echocardiogram score 
      >8 in groups 2, 3, and 4 presented similar combined event-free survival (death, 
      mitral valve replacement, or redo PMV). CONCLUSION: Age is an important predictor 
      of immediate and long-term outcomes after PMV, particularly in patients with 
      optimal mitral valve morphology. (
FAU - Sanchez, Pedro L
AU  - Sanchez PL
AD  - Cardiac Unit, Department of Medicine, Massachusetts General Hospital, Harvard 
      Medical School, Boston, MA 02114, USA.
FAU - Rodriguez-Alemparte, Maximo
AU  - Rodriguez-Alemparte M
FAU - Inglessis, Ignacio
AU  - Inglessis I
FAU - Palacios, Igor F
AU  - Palacios IF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interv Cardiol
JT  - Journal of interventional cardiology
JID - 8907826
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - *Catheterization
MH  - Databases as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*therapy
MH  - *Outcome Assessment, Health Care
MH  - Prospective Studies
EDAT- 2005/08/24 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/08/24 09:00
PHST- 2005/08/24 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/08/24 09:00 [entrez]
AID - JOIC045 [pii]
AID - 10.1111/j.1540-8183.2005.00045.x [doi]
PST - ppublish
SO  - J Interv Cardiol. 2005 Aug;18(4):217-25. doi: 10.1111/j.1540-8183.2005.00045.x.