PMID- 16115604
OWN - NLM
STAT- MEDLINE
DCOM- 20050920
LR  - 20200928
IS  - 1550-8579 (Print)
IS  - 1550-8579 (Linking)
VI  - 2
IP  - 2
DP  - 2005 Jun
TI  - Association of cytosine-adenine repeat polymorphism of the estrogen receptor-beta 
      gene with menopausal symptoms.
PG  - 96-105
AB  - BACKGROUND: The nature and severity of menopausal symptoms are highly variable 
      among women. Polymorphisms of the estrogen receptor-beta (ERbeta) gene, such as 
      cytosine-adenine (CA) dinucleotide repeats in intron 5, have been implicated in 
      various diseases. OBJECTIVE: We investigated the possible role of a CA 
      dinucleotide repeat polymorphism in intron 5 of the ERbeta gene in the occurrence 
      of menopausal and premenstrual symptoms. METHODS: Fifty-one postmenopausal 
      Japanese women were interviewed about premenstrual symptoms, menopausal symptoms, 
      and use of hormone replacement therapy. Menopausal symptoms were divided into 
      vasomotor, psychological, and musculoskeletal symptoms, and summary scores were 
      created on the basis of severity. CA repeat polymorphism of the ERbeta gene was 
      examined using denaturing high-performance liquid chromatography with the WAVE 
      DNA Fragment Analysis System (Transgenomic Inc., Omaha, Nebraska). RESULTS: The 
      number of CA repeats of the ERP gene ranged from 14 to 25, and subjects could be 
      divided into 3 groups: those with < or =17 repeats, or extremely short (E); 18 to 
      21 repeats, or short (S); and > or =22 repeats, or long (L). Four genotypes of CA 
      repeats (EL, SS, SL, and LL) were found among the subjects, with SL being the 
      most common. Relative to subjects with the SL genotype, women with SS had a 
      7.0-fold increased risk of vasomotor symptoms (odds ratio [OR] = 7.0; 95% CI, 
      1.25-39.15; P < 0.05), a 13.0-fold higher risk of psychological symptoms (OR = 
      13.0; 95% CI, 1.44-117.2; P < 0.01), and a 7.6-fold increased risk of 
      premenstrual symptoms (OR = 7.6; 95% CI, 1.61-35.9; P = 0.01). The EL genotype 
      was associated with an increased risk of vasomotor symptoms (P < 0.05), 
      depression (P < 0.01), and premenstrual symptoms (P < 0.01). CONCLUSIONS: CA 
      repeat polymorphism of the ERbeta gene may be associated with menopausal and 
      premenstrual symptoms. Premenstrual symptom scores were significantly related to 
      menopausal symptom scores.
FAU - Takeo, Chikari
AU  - Takeo C
AD  - Department of General Medicine, Chiba Pre fectural Togane Hospital, Chiba, Japan. 
      chikari@prefhosp.togane.chiba.jp
FAU - Negishi, Etsuko
AU  - Negishi E
FAU - Nakajima, Aya
AU  - Nakajima A
FAU - Ueno, Koichi
AU  - Ueno K
FAU - Tatsuno, Ichiro
AU  - Tatsuno I
FAU - Saito, Yasushi
AU  - Saito Y
FAU - Amano, Keiko
AU  - Amano K
FAU - Hirai, Aizan
AU  - Hirai A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gend Med
JT  - Gender medicine
JID - 101225178
RN  - 0 (Estrogen Receptor beta)
RN  - 8J337D1HZY (Cytosine)
RN  - JAC85A2161 (Adenine)
SB  - IM
EIN - Gend Med. 2005 Sep;2(3):183
MH  - Adenine/metabolism
MH  - Cytosine/metabolism
MH  - Depression/epidemiology/genetics
MH  - Dinucleotide Repeats
MH  - Estrogen Receptor beta/*genetics
MH  - Female
MH  - Headache/epidemiology/genetics
MH  - Hot Flashes/epidemiology/genetics
MH  - Humans
MH  - Japan/epidemiology
MH  - Menopause/*genetics
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Polymorphism, Genetic
MH  - Premenstrual Syndrome/*epidemiology/*genetics
MH  - Regression Analysis
EDAT- 2005/08/24 09:00
MHDA- 2005/09/21 09:00
CRDT- 2005/08/24 09:00
PHST- 2005/02/16 00:00 [accepted]
PHST- 2005/08/24 09:00 [pubmed]
PHST- 2005/09/21 09:00 [medline]
PHST- 2005/08/24 09:00 [entrez]
AID - S1550-8579(05)80016-6 [pii]
AID - 10.1016/s1550-8579(05)80016-6 [doi]
PST - ppublish
SO  - Gend Med. 2005 Jun;2(2):96-105. doi: 10.1016/s1550-8579(05)80016-6.