PMID- 16117723
OWN - NLM
STAT- MEDLINE
DCOM- 20060113
LR  - 20151119
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 109
IP  - 6
DP  - 2005 Dec
TI  - Augmentation of endothelial function following exercise training is associated 
      with increased L-arginine transport in human heart failure.
PG  - 523-30
AB  - We have reported previously a decrease in the clearance of the NO (nitric oxide) 
      precursor L-arginine in the forearm circulation of CHF (congestive heart failure) 
      patients, suggesting a potential rate-limiting mechanism contributing to the 
      common finding of endothelial dysfunction in CHF. Given data that show exercise 
      training augments endothelial function in CHF, the aim of the present study was 
      to investigate whether these improvements were due to an increase in L-arginine 
      transport. Measures of L-arginine transport, endothelial function and exercise 
      capacity were repeated before and after 8 weeks of "usual living" or exercise 
      training in 21 CHF patients [NYHA (New York Heart Association) class II/III]. 
      Exercise capacity (6-min walk test) increased following exercise training 
      (496+/-21 to 561+/-17 m; P=0.005), whereas the control group demonstrated no 
      change [488+/-18 to 484+/-21 m; P=ns (not significant)]. Basal FBF (forearm blood 
      flow) remained stable following exercise training (2.68+/-0.55 to 2.46+/-0.32 
      ml.min(-1).100 ml(-1) of tissue) and "usual living" (2.16+/-0.37 to 2.91+/-0.55 
      min(-1).100 ml(-1) of tissue). FBF responses to ACh (acetylcholine) increased 
      following exercise by 49.6+/-17.7% (area under curve; P=0.01) demonstrating 
      augmented endothelial function. FBF responses to SNP (sodium nitroprusside) were 
      also improved following exercise training (30.8+/-8.2%; P=0.02). There was no 
      change in vascular function in the "usual living" group. The clearance of 
      L-arginine was significantly increased following involvement in the exercise 
      programme (69.4+/-7.8 to 101.0+/-9.5 ml/min; P=0.04), whereas there was no change 
      in the "usual living" group (78.4+/-17.5 to 81.0+/-14.9 ml/min; P=ns). In 
      conclusion, the augmentation in endothelial function observed following exercise 
      may be due, in part, to an increase in the transport of L-arginine in CHF 
      patients.
FAU - Parnell, Melinda M
AU  - Parnell MM
AD  - Wynn Department of Metabolic Cardiology, Baker Medical Research Institute, St 
      Kilda Road Central, Melbourne, Victoria 8008, Australia.
FAU - Holst, Diane P
AU  - Holst DP
FAU - Kaye, David M
AU  - Kaye DM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Vasodilator Agents)
RN  - 0 (dimethylarginine)
RN  - 169D1260KM (Nitroprusside)
RN  - 94ZLA3W45F (Arginine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine
MH  - Analysis of Variance
MH  - Arginine/analogs & derivatives/blood/*metabolism
MH  - Biological Transport
MH  - Case-Control Studies
MH  - Endothelium, Vascular/*metabolism
MH  - Exercise Tolerance
MH  - Forearm/blood supply
MH  - Heart Failure/*metabolism/therapy
MH  - Humans
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - Nitroprusside
MH  - *Physical Education and Training
MH  - Regional Blood Flow/drug effects
MH  - Vasodilator Agents/therapeutic use
EDAT- 2005/08/25 09:00
MHDA- 2006/01/18 09:00
CRDT- 2005/08/25 09:00
PHST- 2005/08/25 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/08/25 09:00 [entrez]
AID - CS20050171 [pii]
AID - 10.1042/CS20050171 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2005 Dec;109(6):523-30. doi: 10.1042/CS20050171.