PMID- 16117862
OWN - NLM
STAT- MEDLINE
DCOM- 20050908
LR  - 20051207
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 118
IP  - 14
DP  - 2005 Jul 20
TI  - Assessment of left ventricular segmental function after autologous bone marrow 
      stem cells transplantation in patients with acute myocardial infarction by tissue 
      tracking and strain imaging.
PG  - 1175-81
AB  - BACKGROUND: Emerging evidence suggests that stem cells can be used to improve 
      cardiac function in patients after acute myocardial infarction. In this 
      randomized trial, we aimed to use Doppler tissue tracking and strain imaging to 
      assess left ventricular segmental function after intracoronary transfer of 
      autologous bone-marrow stem cells (BMCs) for 6 months' follow up. METHODS: Twenty 
      patients with acute myocardial infarction and anterior descending coronary artery 
      occlusion proven by angiography were [corrected] randomized into intracoronary 
      injection of bone-marrow cell (treated, n = 9) or diluted serum (control, n = 11) 
      groups. GE vivid 7 and Q-analyze software were used to perform echocardiogram in 
      both groups 1 week, 3 months and 6 months after treatment. Three apical views of 
      tissue Doppler imaging were acquired to measure peak systolic displacement (Ds) 
      and peak systolic strain (epsilonpeak) from 12 segments of LV walls. Left 
      ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic 
      volume (ESV) were obtained by Simposon's biplane method. RESULTS: (1) 3 months 
      later, Ds and epsilonpeak over the infract-related region clearly increased in 
      the BMCs group [Ds: (4.49 +/- 2.71) mm vs (7.56 +/- 2.95) mm, P < 0.01; 
      epsilonpeak: (-13.40 +/- 6.00)% vs (-17.06 +/- 6.05)%, P < 0.01], but not in the 
      control group [Ds: (4.74 +/- 2.67) mm vs (5.01 +/- 3.23) mm, P > 0.05; 
      epsilonpeak: (-13.84 +/- 6.05)% vs (-15.04 +/- 6.75)%, P > 0.05]. At the same 
      time, Ds over the normal region also increased, but the Ds enhancement was 
      markedly higher in the BMCs group than that in the control group [(3.21 +/- 3.17) 
      mm vs (0.76 +/- 1.94) mm, P < 0.01]. Parameters remained steady from the 3rd to 
      6th month in either group (P > 0.05). (2) LVEF in treated and control groups were 
      almost the same at baseline (1st week after PCI) [(53.37 +/- 8.92)% vs (53.51 +/- 
      5.84)%, P > 0.05]. But 6 months later, LVEF in the BMCs group were clearly higher 
      than that in the control group [(59.33 +/- 12.91)% vs (50.30 +/- 8.30)%, P < 
      0.05]. (3) There were no evident difference in EDV or ESV between two groups at 
      baseline [EDV: (113.74 +/- 23.24) ml vs (129.94 +/- 32.72) ml, P > 0.05; ESV: 
      (57.12 +/- 18.66) ml vs (62.09 +/- 17.68) ml, P > 0.05]. Three months later, EDV 
      and ESV in the control group were markedly greater than those in the BMCs group 
      [EDV: (154.89 +/- 46.34) ml vs (104.85 +/- 33.21) ml, P < 0.05; ESV: (82.91 +/- 
      35.79) ml vs (49.54 +/- 23.32) ml, P < 0.05]. But EDV and ESV did not change much 
      from 3rd to 6th month in either group (P > 0.05). CONCLUSIONS: Emergency 
      transplantation of autologous BMCs in patients with acute myocardial infarction 
      helps to improve global and regional contractility and attenuate post-infarction 
      left ventricular remodeling. Tissue tracking and strain imaging provide quick, 
      simple and noninvasive methods for quantifying left ventricular segmental 
      function in humans.
FAU - Ruan, Wen
AU  - Ruan W
AD  - Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai 
      200032, China.
FAU - Pan, Cui-zhen
AU  - Pan CZ
FAU - Huang, Guo-qian
AU  - Huang GQ
FAU - Li, Yan-lin
AU  - Li YL
FAU - Ge, Jun-bo
AU  - Ge JB
FAU - Shu, Xian-hong
AU  - Shu XH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
EIN - Chin Med J (Engl). 2005 Nov 20;118(22):1906
MH  - Aged
MH  - Double-Blind Method
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*physiopathology/*therapy
MH  - Transplantation, Autologous
MH  - *Ventricular Function, Left
MH  - Ventricular Remodeling
EDAT- 2005/08/25 09:00
MHDA- 2005/09/09 09:00
CRDT- 2005/08/25 09:00
PHST- 2005/08/25 09:00 [pubmed]
PHST- 2005/09/09 09:00 [medline]
PHST- 2005/08/25 09:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2005 Jul 20;118(14):1175-81.