PMID- 1611993
OWN - NLM
STAT- MEDLINE
DCOM- 19920727
LR  - 20071114
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 131
IP  - 1
DP  - 1992 Jul
TI  - Detection of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in the 
      uterus during the second half of pregnancy in the mouse.
PG  - 14-20
AB  - This study demonstrated interleukin-1 (IL-1), IL-6, and tumor necrosis 
      factor-alpha (TNF alpha) in the mouse uterus during the second half of pregnancy 
      (days 9-18). High concentrations of IL-1 alpha mRNA and bioactive IL-1 were 
      detected between days 12-17. IL-1 bioactivity decreased to very low levels as 
      pregnancy approached parturition. IL-6 mRNA was detected from days 9-18, and IL-6 
      bioactivity approximately paralleled IL-1 bioactivity. High levels of IL-1 and 
      IL-6 bioactivity, but not IL-1 or IL-6 mRNA, were detected in the placenta 
      between days 12-17. Placental IL-1 and IL-6 also decreased to low levels near 
      parturition. TNF alpha was expressed from days 9-17, and a peak of TNF alpha 
      bioactivity was detected during the period immediately before parturition. TNF 
      alpha mRNA and TNF alpha bioactivity were not detected in the placenta. On day 
      18, the day of parturition, the concentrations of IL-1, IL-6, and TNF alpha mRNA 
      were very low relative to those on other pregnancy days. Immunocytochemistry with 
      antibodies to IL-1, IL-6, and TNF alpha was used to confirm the presence of all 
      three cytokines in uterine cells throughout the second half of pregnancy. Those 
      data showing the kinetics of cytokine production during fetal development raise 
      the possibility that cytokines and cytokine-induced mediators modulate cellular 
      events during the late stages of pregnancy in the mouse.
FAU - De, M
AU  - De M
AD  - Department of Pathology and Oncology, University of Kansas Medical Center, Kansas 
      City 66103.
FAU - Sanford, T H
AU  - Sanford TH
FAU - Wood, G W
AU  - Wood GW
LA  - eng
GR  - HD-17678/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Female
MH  - Immunoenzyme Techniques
MH  - Interleukin-1/*biosynthesis/genetics
MH  - Interleukin-6/*biosynthesis/genetics
MH  - Mice
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/genetics
MH  - Uterus/*metabolism
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1210/endo.131.1.1611993 [doi]
PST - ppublish
SO  - Endocrinology. 1992 Jul;131(1):14-20. doi: 10.1210/endo.131.1.1611993.