PMID- 16120736
OWN - NLM
STAT- MEDLINE
DCOM- 20051129
LR  - 20190101
IS  - 1079-2082 (Print)
IS  - 1079-2082 (Linking)
VI  - 62
IP  - 17
DP  - 2005 Sep 1
TI  - Patient factors associated with adherence to immunosuppressant therapy in renal 
      transplant recipients.
PG  - 1775-81
AB  - PURPOSE: Factors associated with adherence to immunosuppressant therapy (IST) in 
      renal transplant recipients were studied. METHODS: The Immunosuppressant Therapy 
      Adherence Scale (ITAS) was completed by adult renal transplant recipients in 
      Georgia. Those completing the ITAS were classified as adherent to IST if their 
      ITAS score were 12 and nonadherent if their score was less than 12. The 
      relationship between the dichotomized ITAS scores and patient variables that are 
      readily available to clinicians, such as sex, age, kidney donor type, income, 
      marital status, race or ethnicity, and time since transplantation, was assessed. 
      The relationship of ITAS scores to patients' clinical and pharmacy data (e.g., 
      graft rejection, serum IST concentrations, serum creatinine [SCr] concentrations, 
      and pharmacy refill-based adherence rates) was also assessed. RESULTS: One 
      hundred thirty-seven patients completed the ITAS. Eighty-nine patients (65%) were 
      adherent to IST, and the remaining 48 (35%) were nonadherent. Patient sex was 
      unrelated to adherence. Compared with nonadherent patients, adherent patients 
      tended to be younger, to take cyclosporine, to have lower incomes, to have 
      received their transplant more recently, to have targeted immunosuppressant 
      concentrations, to have greater refill-based adherence rates, and to be less 
      likely to exhibit an increase in SCr concentration (p < 0.05). There was no 
      significant difference in the number of rejections between adherent and 
      nonadherent patients. CONCLUSION: Patient age, income, time since 
      transplantation, and the immunosuppressant agent prescribed were associated with 
      IST adherence.
FAU - Chisholm, Marie A
AU  - Chisholm MA
AD  - College of Pharmacy, University of Georgia (UG), Augusta, 30912, USA. 
      mchishol@mail.mcg.edu
FAU - Lance, Charles E
AU  - Lance CE
FAU - Mulloy, Laura L
AU  - Mulloy LL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Health Syst Pharm
JT  - American journal of health-system pharmacy : AJHP : official journal of the 
      American Society of Health-System Pharmacists
JID - 9503023
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Cyclosporine/administration & dosage/blood/*therapeutic use
MH  - Female
MH  - Georgia
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/blood/*therapeutic use
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance/*statistics & numerical data
MH  - Records
MH  - Social Class
MH  - Surveys and Questionnaires
EDAT- 2005/08/27 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/27 09:00
PHST- 2005/08/27 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/27 09:00 [entrez]
AID - 62/17/1775 [pii]
AID - 10.2146/ajhp040541 [doi]
PST - ppublish
SO  - Am J Health Syst Pharm. 2005 Sep 1;62(17):1775-81. doi: 10.2146/ajhp040541.