PMID- 16122188
OWN - NLM
STAT- MEDLINE
DCOM- 20051207
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 26
IP  - 4
DP  - 2005
TI  - Loss of basement membrane heparan sulfate expression is associated with tumor 
      progression in endometrial cancer.
PG  - 403-6
AB  - Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane 
      (BM) and binds to various cytokines and growth factors via its heparan sulfate 
      glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM 
      HS-GAG expression in endometrial cancers. We investigated the expression of BM 
      HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed 
      correlations with various clinicopathological features. The HS-GAG expression 
      index was significantly lower in cases of advanced stage, high-grade, deep 
      myometrial invasion, positive peritoneal cytology, lymph vascular space invasion 
      and lymph node metastasis. There was no association between HS-GAG expression 
      status and patient outcome. Decreased HS-GAG expression of BM is associated with 
      tumor progression, but is not be a useful prognostic factor in patients 
      presenting with endometrial cancer.
FAU - Hasengaowa
AU  - Hasengaowa
AD  - Department of Obstetrics and Gynecology, Okayama University Graduate School of 
      Medicine and Dentistry, Okayama, Japan.
FAU - Kodama, J
AU  - Kodama J
FAU - Kusumoto, T
AU  - Kusumoto T
FAU - Shinyo, Y
AU  - Shinyo Y
FAU - Seki, N
AU  - Seki N
FAU - Nakamura, K
AU  - Nakamura K
FAU - Hongo, A
AU  - Hongo A
FAU - Hiramatsu, Y
AU  - Hiramatsu Y
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
RN  - 0 (Heparan Sulfate Proteoglycans)
RN  - 143972-95-6 (perlecan)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Basement Membrane/*metabolism/physiopathology
MH  - Carcinoma, Adenosquamous/*metabolism/pathology/surgery
MH  - Carcinoma, Endometrioid/*metabolism/pathology/surgery
MH  - Disease Progression
MH  - Endometrial Neoplasms/*metabolism/pathology/surgery
MH  - Female
MH  - Gynecologic Surgical Procedures
MH  - Heparan Sulfate Proteoglycans/*biosynthesis
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
EDAT- 2005/08/27 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/08/27 09:00
PHST- 2005/08/27 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/08/27 09:00 [entrez]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2005;26(4):403-6.