PMID- 16123537
OWN - NLM
STAT- MEDLINE
DCOM- 20051025
LR  - 20060328
IS  - 1534-0384 (Print)
IS  - 1534-0384 (Linking)
VI  - 5
IP  - 4
DP  - 2005 Aug
TI  - Hanging in the balance. KIR and their role in disease.
PG  - 226-40
AB  - The killer cell immunoglobulin-like receptors (KIR) are a recently discovered 
      family of activating and inhibitory receptors that control natural killer (NK) 
      cell function. KIR exist as a diverse family of receptors that have evolved 
      rapidly by both gene duplication and recombination events. These findings were 
      unexpected for a family of genes involved primarily in the innate immune 
      response. These findings together with the observation that several of these 
      genes have human leukocyte antigen (HLA) class I ligands, have led to a flurry of 
      investigation into how KIR participate in viral infections, autoimmune diseases 
      and malignancies. This review summarizes the major features of these genes and 
      discusses how they may be involved in both disease pathogenesis and its 
      amelioration.
FAU - Williams, Anthony P
AU  - Williams AP
AD  - Division of Cancer Sciences, Southampton University School of Medicine, 
      Southampton, UK, SO16 6YD. apw2@soton.ac.uk
FAU - Bateman, Andrew R
AU  - Bateman AR
FAU - Khakoo, Salim I
AU  - Khakoo SI
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mol Interv
JT  - Molecular interventions
JID - 101093789
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology
MH  - Cytomegalovirus Infections/immunology
MH  - Evolution, Molecular
MH  - Female
MH  - Genotype
MH  - HIV Infections/immunology
MH  - HLA Antigens
MH  - Hematologic Diseases/immunology
MH  - Hepatitis C/immunology
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Immune System/physiology
MH  - Killer Cells, Natural/*metabolism
MH  - Multigene Family
MH  - Neoplasms/immunology
MH  - Pregnancy
MH  - *Receptors, Immunologic/genetics/metabolism
RF  - 130
EDAT- 2005/08/27 09:00
MHDA- 2005/10/26 09:00
CRDT- 2005/08/27 09:00
PHST- 2005/08/27 09:00 [pubmed]
PHST- 2005/10/26 09:00 [medline]
PHST- 2005/08/27 09:00 [entrez]
AID - 5/4/226 [pii]
AID - 10.1124/mi.5.4.6 [doi]
PST - ppublish
SO  - Mol Interv. 2005 Aug;5(4):226-40. doi: 10.1124/mi.5.4.6.