PMID- 16124648
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20140625
VI  - 19
IP  - 11
DP  - 2005 Jun
TI  - [The expression and correlation of eIF4E and VEGF in laryngeal squamous cell 
      carcinoma].
PG  - 501-3
AB  - OBJECTIVE: To study the expression and correlation of eIF4E and VEGF in laryngeal 
      squamous cell carcinoma (LSCC). METHOD: Western-blot analysis was performed on 
      tumor core,transition core, "tumor-free" core of 20 specimens of fresh LSCC by 
      using anti-eIF4E and VEGF antiserums. RESULT: The expression of eIF4E protein 
      level from "tumor-free" core, transition core and tumor core of LSCC appeared 
      progressive overexpression. It appeared that there was significant elevation of 
      VEGF protein level in tumor core compared with tumor transition and "tumor-free" 
      core. There appeared to be statistically significantly correlation of eIF4E and 
      VEGF expression. CONCLUSION: Overexpression of eIF4E may be a molecular marker of 
      malignant transformation and progression. The overexpression of VEGF is highly 
      associated with the growth and metastasis of LSCC, and may be of prognostic 
      value. The correlation of eIF4E and VEGF may serve as a potential target for 
      antiangiogenic therapy of LSCC.
FAU - Wang, Binquan
AU  - Wang B
AD  - Department of Otolaryngology, the First Hospital of Shanxi Medical University, 
      Taiyuan, 030001, China. wbqxx@public.ty.sx.cn
FAU - Zhang, Haili
AU  - Zhang H
FAU - Chen, Yanqiu
AU  - Chen Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Eukaryotic Initiation Factor-4E/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Prognosis
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2005/08/30 09:00
MHDA- 2011/06/07 06:00
CRDT- 2005/08/30 09:00
PHST- 2005/08/30 09:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PHST- 2005/08/30 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jun;19(11):501-3.