PMID- 16125500
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20161124
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 96
IP  - 5
DP  - 2005 Sep 1
TI  - Prognostic value of plasma brain natriuretic peptide, urea nitrogen, and 
      creatinine in outpatients >70 years of age with heart failure.
PG  - 705-9
AB  - This study analyzed the relevance of plasma brain natriuretic peptide (BNP) and 
      echocardiography in predicting cardiovascular events in a large population >70 
      years old with heart failure (HF). Three hundred four outpatients with HF (51.6% 
      men, mean age 78.6) underwent transthoracic echocardiography and plasma BNP 
      testing shortly before hospital discharge. Echocardiography was intended to 
      reveal systolic dysfunction (left ventricular [LV] ejection fraction [EF] <50%) 
      or diastolic dysfunction (EF > or =50% and abnormalities of ventricular 
      relaxation). During 6-month follow-up, all-cause death and readmission were 
      assessed. One hundred seventeen patients had diastolic dysfunction with preserved 
      systolic LV function, and 187 had systolic dysfunction. At 6-month clinical 
      follow-up, 33 subjects (10.9%) had died, and 62 (20.4%) needed readmission for 
      cardiac decompensation. In all patients, univariate logistic regression 
      demonstrated significant correlations between age (r = 0.14, p = 0.01), plasma 
      BNP (r = 0.36, p = 0.0001), the EF (r = 0.16, p = 0.003), urea nitrogen (r = 
      0.35, p = 0.0001), serum creatinine (r = 0.27, p = 0.0001), and New York Heart 
      Association (NYHA) class (r = 0.35, p = 0.0001) and the occurrence of 
      cardiovascular events. In patients with HF in NYHA class III or IV, a BNP cut-off 
      level of 200 pg/ml identified different outcomes (BNP <200 pg/ml in 1 of 20 
      events vs BNP >200 pg/ml in 55 of 85 events, p = 0.0001). In patients with HF who 
      were >70 years old, BNP, NYHA class, and renal function predicted adverse 
      outcome. In patients with severe HF, BNP was better than NYHA class in predicting 
      future events.
FAU - Feola, Mauro
AU  - Feola M
AD  - Department of Cardiovascular Diseases, Ospedale S. Croce, Carle Cuneo, Italy. 
      m_feola@virgilio.it
FAU - Aspromonte, Nadia
AU  - Aspromonte N
FAU - Canali, Cristina
AU  - Canali C
FAU - Ceci, Vincenzo
AU  - Ceci V
FAU - Giovinazzo, Prospero
AU  - Giovinazzo P
FAU - Milani, Loredano
AU  - Milani L
FAU - Quarta, Giovanni
AU  - Quarta G
FAU - Ricci, Roberto
AU  - Ricci R
FAU - Scardovi, Angela Beatrice
AU  - Scardovi AB
FAU - Uslenghi, Eugenio
AU  - Uslenghi E
FAU - Valle, Roberto
AU  - Valle R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - *Blood Urea Nitrogen
MH  - Creatinine/*blood
MH  - Echocardiography
MH  - Female
MH  - Fluorescence Polarization Immunoassay
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - *Outpatients
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Ventricular Function, Left/physiology
EDAT- 2005/08/30 09:00
MHDA- 2005/10/07 09:00
CRDT- 2005/08/30 09:00
PHST- 2005/01/17 00:00 [received]
PHST- 2005/04/11 00:00 [revised]
PHST- 2005/04/11 00:00 [accepted]
PHST- 2005/08/30 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2005/08/30 09:00 [entrez]
AID - S0002-9149(05)00945-8 [pii]
AID - 10.1016/j.amjcard.2005.04.049 [doi]
PST - ppublish
SO  - Am J Cardiol. 2005 Sep 1;96(5):705-9. doi: 10.1016/j.amjcard.2005.04.049.