PMID- 16127003
OWN - NLM
STAT- MEDLINE
DCOM- 20060626
LR  - 20061115
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1051
DP  - 2005 Jun
TI  - Intra-bone marrow-bone marrow transplantation: a new strategy for treatment of 
      stem cell disorders.
PG  - 626-34
AB  - We have established new bone marrow transplantation (BMT) methods for the 
      treatment of stem cell disorders such as autoimmune diseases. The methods include 
      the perfusion method (PM) and intra-bone marrow (IBM)-BMT. PM, in comparison with 
      the conventional aspiration method, can minimize the contamination of bone marrow 
      cells (BMCs) with T cells from the peripheral blood. Therefore, without removing 
      T cells, no graft-versus-host disease develops in the case of PM. Because BMCs 
      collected using the PM contain not only hemopoietic stem cells (HSCs) but also 
      mesenchymal stem cells (MSCs), the injection of both cells directly into the bone 
      marrow cavity (IBM-BMT) facilitates the engraftment of donor hemopoietic cells. 
      With IBM-BMT, no graft failure therefore occurs even if the radiation dose is 
      reduced. IBM-BMT is applicable to regeneration therapy and various age-associated 
      diseases such as osteoporosis, because it can efficiently recruit donor-derived 
      normal MSCs into the bone marrow. We believe that this strategy heralds a 
      revolution in the field of transplantation and regenerative therapy.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - First Department of Pathology, Transplantation Center, Regeneration Research 
      Center for Intractable Diseases, and Center for Cancer Therapy, Kansai Medical 
      University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan. 
      ikehara@takii.kmu.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/*therapy
MH  - Bone Marrow Transplantation/*methods
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mice
MH  - Stromal Cells/physiology
RF  - 40
EDAT- 2005/08/30 09:00
MHDA- 2006/06/27 09:00
CRDT- 2005/08/30 09:00
PHST- 2005/08/30 09:00 [pubmed]
PHST- 2006/06/27 09:00 [medline]
PHST- 2005/08/30 09:00 [entrez]
AID - 1051/1/626 [pii]
AID - 10.1196/annals.1361.107 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2005 Jun;1051:626-34. doi: 10.1196/annals.1361.107.