PMID- 16128330
OWN - NLM
STAT- MEDLINE
DCOM- 20051020
LR  - 20220317
IS  - 1081-597X (Print)
IS  - 1081-597X (Linking)
VI  - 21
IP  - 4
DP  - 2005 Jul-Aug
TI  - Descemet's stripping with endothelial keratoplasty in 50 eyes: a refractive 
      neutral corneal transplant.
PG  - 339-45
AB  - PURPOSE: To evaluate early visual and refractive outcomes following treatment of 
      corneal endothelial dysfunction with a corneal transplantation technique, 
      Descemet's stripping with endothelial keratoplasty (DSEK). METHODS: Visual and 
      refractive outcomes of the first 50 consecutive cases of DSEK performed by a 
      single surgeon between December 2003 and July 2004 were analyzed retrospectively. 
      The DSEK technique consisted of stripping Descemet's membrane and endothelium 
      from a recipient cornea and transplanting the posterior stroma and endothelium of 
      a donor cornea through a 5-mm incision. RESULTS: Results are reported for 50 eyes 
      in 47 patients (30 women and 17 men). Mean patient age at surgery was 70 +/- 12 
      years (range: 34 to 89 years). Five eyes were treated for corneal edema or 
      bullous keratopathy and 45 for Fuchs' endothelial dystrophy. Seven eyes were 
      phakic and 43 were pseudophakic. Six months after surgery, mean manifest cylinder 
      was 1.5 +/- 0.94 diopters (D), unchanged from preoperative cylinder of 1.5 +/- 
      1.0 D. Mean manifest spherical equivalent refraction was 0.15 +/- 1.5 D at 
      6-month follow-up compared with -0.36 +/- 1.4 D preoperatively (P = .10) At 3- 
      and 6-month follow-up, significant improvement was noted in mean best 
      spectacle-corrected visual acuity compared with the preoperative mean of 20/100 
      (P = .007). At 6-month follow-up, 31 (62%) eyes refracted to > or = 20/40 and 38 
      (76%) eyes saw > or = 20/50. CONCLUSIONS: Compared to standard penetrating 
      keratoplasty, DSEK causes minimal refractive change and provides rapid visual 
      recovery for patients with endothelial dysfunction. This technique maintains the 
      structural integrity of the cornea by preserving the recipient's epithelium, 
      Bowman's layer, and entire stromal thickness.
FAU - Price, Francis W Jr
AU  - Price FW Jr
AD  - Price Vision Group, 9002 N Meridian St, Ste 100, Indianapolis, IN 46260, USA. 
      fprice@pricevisiongroup.net
FAU - Price, Marianne O
AU  - Price MO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Refract Surg
JT  - Journal of refractive surgery (Thorofare, N.J. : 1995)
JID - 9505927
SB  - IM
CIN - J Refract Surg. 2006 Jun;22(6):529-30; author reply 530. PMID: 16805114
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Corneal Diseases/complications/*surgery
MH  - Corneal Transplantation/*methods
MH  - Descemet Membrane/*surgery
MH  - Endothelium, Corneal/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Refraction, Ocular
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
EDAT- 2005/09/01 09:00
MHDA- 2005/10/21 09:00
CRDT- 2005/09/01 09:00
PHST- 2005/09/01 09:00 [pubmed]
PHST- 2005/10/21 09:00 [medline]
PHST- 2005/09/01 09:00 [entrez]
AID - 10.3928/1081-597X-20050701-07 [doi]
PST - ppublish
SO  - J Refract Surg. 2005 Jul-Aug;21(4):339-45. doi: 10.3928/1081-597X-20050701-07.