PMID- 16129026
OWN - NLM
STAT- MEDLINE
DCOM- 20060313
LR  - 20181113
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 4
DP  - 2005 Aug 29
TI  - Hazardous waste sites and stroke in New York State.
PG  - 18
AB  - BACKGROUND: Environmental exposure to persistent organic pollutants (POPs) may 
      lead to elevation of serum lipids, increasing risk of atherosclerosis with 
      thromboembolism, a recognized cause of stroke. We tested the hypothesis that 
      exposure to contaminants from residence near hazardous waste sites in New York 
      State influences the occurrence of stroke. METHODS: The rates of stroke hospital 
      discharges were compared among residents of zip codes containing hazardous waste 
      sites with POPs, other pollutants or without any waste sites using information 
      for 1993-2000 from the New York Statewide Planning and Research Cooperative 
      System (SPARCS) database, containing the records of all discharge diagnoses for 
      patients admitted to state-regulated hospitals. RESULTS: After adjustment for age 
      and race, the hospitalization rate for stroke in zip codes with POPs-contaminated 
      sites was 15% higher than in zip codes without any documented hazardous waste 
      sites (RR 1.15, 95% CI, 1.05, 1.26). For ischemic stroke only, the RR was 1.17 
      (95% CI 1.04, 1.31). Residents of zip codes containing other waste sites showed a 
      RR of 1.13 (95% CI, 1.02, 1.24) as compared to zip codes without an identified 
      waste site. CONCLUSION: These results suggest that living near a source of POPs 
      contamination constitutes a risk of exposure and an increased risk of acquiring 
      cerebrovascular disease. However further research with better control of 
      individual risk factors and direct measurement of exposure is necessary for 
      providing additional support for this hypothesis.
FAU - Shcherbatykh, Ivan
AU  - Shcherbatykh I
AD  - Department of Environmental Health and Toxicology, School of Public Health, 
      University at Albany, SUNY, One University Place, Rensselaer, NY 12144, USA. 
      shcheriy@mcmaster.ca
FAU - Huang, Xiaoyu
AU  - Huang X
FAU - Lessner, Lawrence
AU  - Lessner L
FAU - Carpenter, David O
AU  - Carpenter DO
LA  - eng
GR  - D43 TW000636/TW/FIC NIH HHS/United States
GR  - 5D43TW00636/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050829
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Waste)
RN  - 0 (Polycyclic Compounds)
SB  - IM
MH  - Adult
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Hazardous Waste/*adverse effects
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New York/epidemiology
MH  - Patient Discharge
MH  - Polycyclic Compounds/*toxicity
MH  - Postal Service
MH  - Stroke/*epidemiology/etiology
PMC - PMC1236948
EDAT- 2005/09/01 09:00
MHDA- 2006/03/15 09:00
PMCR- 2005/08/29
CRDT- 2005/09/01 09:00
PHST- 2005/04/28 00:00 [received]
PHST- 2005/08/29 00:00 [accepted]
PHST- 2005/09/01 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2005/09/01 09:00 [entrez]
PHST- 2005/08/29 00:00 [pmc-release]
AID - 1476-069X-4-18 [pii]
AID - 10.1186/1476-069X-4-18 [doi]
PST - epublish
SO  - Environ Health. 2005 Aug 29;4:18. doi: 10.1186/1476-069X-4-18.