PMID- 16130198
OWN - NLM
STAT- MEDLINE
DCOM- 20051122
LR  - 20181113
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 6
IP  - 9
DP  - 2005 Sep
TI  - Study of androgen and atherosclerosis in old-age male.
PG  - 931-5
AB  - OBJECTIVE: To observe the difference of androgen and inflammatory cytokines level 
      in atherosclerosis and analyse their relations. METHOD: Both carotid arteries and 
      arteries of lower extremity were subjected to ultrasonic examination by Doppler's 
      method. Those with much atheromatous plaque formation were ranged into case 
      group, and those with normal result formed control group. Total, free 
      testosterone and estradiol were assayed by radioimmunoassay. C reactive protein 
      (CRP) was assayed by nepheloturbidity. Tumor necrosis factor-alpha (TNF-alpha), 
      Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), 
      Interleukin-18 (IL-18), soluble intercellular adhesion molecule-1 (sICAM-1) and 
      soluble vascular cell adhesion molecule-1 (sVCAM-1) were assayed by ELISA. The 
      mean difference between two groups and the correlation between free testosterone 
      and cytokines were analysed. RESULTS: Free testosterone was (6.337+/-3.371) pg/L 
      in case group and (11.375+/-4.733) pg/L in control group, P<0.01. No differences 
      were found in total testosterone and estradiol. CRP was (27.294+/-10.238) mg/L in 
      case group and (12.843+/-6.318) mg/L in control group, P<0.01. IL-6 was 
      (41.700+/-31.385) pg/L in case group and (25.396+/-20.772) pg/L in control group, 
      P<0.05. IL-8 was (89.249+/-58.357) pg/L in case group and (67.873+/-31.227) pg/L 
      in control group, P<0.05. sICAM-1 was (470.491+/-134.078) pg/L in case group and 
      (368.487+/-97.183) pg/L in control group, P<0.01. sVCAM-1 was (537.808+/-213.172) 
      pg/L in case group and (457.275+/-157.273) pg/L in control group, P<0.05. There 
      were no differences in TNF-alpha, IL-10 and IL-18. Correlation analysis showed 
      that FT (free testosterone) had negative correlation with CRP, IL-6 and sICAM-1. 
      Among them FT had well correlation with CRP, correlation index was -0.678. 
      CONCLUSION: Free testosterone was in negative correlation with atherosclerosis in 
      old-age male. Free testosterone may have the role of anti-atherosclerosis, and 
      this effect was not achieved by its transformation to estradiol. Low free 
      testosterone level was followed by increased level of inflammatory cytokines. Low 
      free testosterones coexist with inflammation and they both affect the process of 
      atherosclerosis in old-age male.
FAU - Yang, Yun-Mei
AU  - Yang YM
AD  - Department of Very Important People, First Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou 310003, China.
FAU - Lv, Xue-Ying
AU  - Lv XY
FAU - Huang, Wei-Dong
AU  - Huang WD
FAU - Xu, Zhe-Rong
AU  - Xu ZR
FAU - Wu, Ling-Jiao
AU  - Wu LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Androgens)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Androgens/*blood
MH  - Atherosclerosis/*blood
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - Estradiol/blood
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Testosterone/blood
PMC - PMC1389914
EDAT- 2005/09/01 09:00
MHDA- 2005/12/13 09:00
PMCR- 2005/09/01
CRDT- 2005/09/01 09:00
PHST- 2005/09/01 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/01 09:00 [entrez]
PHST- 2005/09/01 00:00 [pmc-release]
AID - 10.1631/jzus.2005.B0931 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2005 Sep;6(9):931-5. doi: 10.1631/jzus.2005.B0931.