PMID- 16134722
OWN - NLM
STAT- MEDLINE
DCOM- 20050920
LR  - 20190911
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 34
IP  - 3
DP  - 2005 May-Jun
TI  - Genetic aspects of rheumatic diseases.
PG  - 167-77
AB  - In this review on the genetic aspects of rheumatic diseases, the approach was 
      taken (i) to discuss, in general, important principles in the identification of 
      susceptibility genes and (ii) to focus on five autoimmune rheumatic diseases that 
      have the characteristics of complex diseases and in which important advances have 
      been made in the identification of the genetic component. A decade ago, most 
      reviews on the genetics of rheumatic diseases focused almost exclusively on a 
      discussion of the human leukocyte antigen (HLA) but in this fast-moving field it 
      is now apparent that genes outside the HLA also contribute to susceptibility. 
      Current hypotheses concerning the pathogenesis of autoimmunity have led to the 
      inclusion of hundreds of genes as potential candidates. Almost any molecule 
      involved in immune recognition, cell interaction, intracellular signalling, 
      cytokine pathways or programmed cell death can be reasonably proposed. The 
      identification of the genes involved in complex diseases will contribute to an 
      understanding of disease mechanisms and disease biology. The disease pathways by 
      which the genes exert their effects or functions could lead to the discovery of 
      new therapeutic targets that may be modulated. An increased understanding of the 
      interactions between genes and environment might also be attained.
FAU - Steinsson, K
AU  - Steinsson K
AD  - Center for Rheumatology Research, Landspitali-University Hospital, Reykjavik, 
      Iceland. krstein@landspitali.is
FAU - Alarcon-Riquelme, M E
AU  - Alarcon-Riquelme ME
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
SB  - IM
MH  - Autoimmunity/*genetics
MH  - *Environmental Exposure
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Rheumatic Diseases/*genetics
RF  - 130
EDAT- 2005/09/02 09:00
MHDA- 2005/09/21 09:00
CRDT- 2005/09/02 09:00
PHST- 2005/09/02 09:00 [pubmed]
PHST- 2005/09/21 09:00 [medline]
PHST- 2005/09/02 09:00 [entrez]
AID - 10.1080/03009740510026779 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2005 May-Jun;34(3):167-77. doi: 10.1080/03009740510026779.