PMID- 16134999
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20171116
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60
IP  - 10
DP  - 2005 Oct
TI  - High prevalence of IgE antibodies among blood donors in Sweden and Norway.
PG  - 1312-5
AB  - BACKGROUND: Reactions after a blood transfusion could be allergic because of 
      passive transfer of immunoglobulin E (IgE) antibodies from allergic donors. AIMS 
      OF THE STUDY: To compare spectrum and prevalence of IgE antibodies in blood 
      donors from Sweden and Norway. METHODS: Using the ImmunoCAP method, serum samples 
      from 1002 blood donors from Sweden and 500 from Norway were analysed for IgE 
      antibodies to common inhalant and food allergens and allergens common in a 
      hospital environment, such as penicilloyl G and latex. RESULTS: As many as 
      23.6-27.3% of the donors had IgE antibodies to at least one of the 14 allergens 
      tested. Of these 6.8-16.7% had extremely high concentrations, i.e. >35 kU(A)/l 
      corresponding to 100 times the cut-off for a positive allergy test. Most donors 
      were sensitized to pollens, dander and mite but several had very high levels of 
      IgE antibodies to penicilloyl G, latex and peanut. The pattern of sensitizing 
      allergens differed between Sweden and Norway. CONCLUSIONS: High serum levels of 
      IgE antibodies to various allergens are common among blood donors and the degree 
      of sensitization and spectrum of involved allergen varies between geographical 
      regions. Present routines to identify IgE sensitized, potential risk, donors are 
      not satisfactory; the sensitivity of selection procedures is about 25%.
FAU - Johansson, S G O
AU  - Johansson SG
AD  - Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Nopp, A
AU  - Nopp A
FAU - Florvaag, E
AU  - Florvaag E
FAU - Lundahl, J
AU  - Lundahl J
FAU - Soderstrom, T
AU  - Soderstrom T
FAU - Guttormsen, A B
AU  - Guttormsen AB
FAU - Hervig, T
AU  - Hervig T
FAU - Lundberg, M
AU  - Lundberg M
FAU - Oman, H
AU  - Oman H
FAU - van Hage, M
AU  - van Hage M
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Latex)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - J2R869A8YF (Succinylcholine)
SB  - IM
MH  - Allergens/adverse effects/*immunology
MH  - Animals
MH  - *Blood Donors
MH  - Food Hypersensitivity/epidemiology/etiology
MH  - Humans
MH  - Hypersensitivity, Immediate/*epidemiology/etiology
MH  - Immunoglobulin E/*blood
MH  - Latex/immunology
MH  - Norway/epidemiology
MH  - Prevalence
MH  - Respiratory Hypersensitivity/epidemiology/etiology
MH  - Succinylcholine/immunology
MH  - Sweden/epidemiology
MH  - Transfusion Reaction
EDAT- 2005/09/02 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/09/02 09:00
PHST- 2005/09/02 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/09/02 09:00 [entrez]
AID - ALL896 [pii]
AID - 10.1111/j.1398-9995.2005.00896.x [doi]
PST - ppublish
SO  - Allergy. 2005 Oct;60(10):1312-5. doi: 10.1111/j.1398-9995.2005.00896.x.