PMID- 16136506
OWN - NLM
STAT- MEDLINE
DCOM- 20060106
LR  - 20170327
IS  - 0213-3911 (Print)
IS  - 0213-3911 (Linking)
VI  - 20
IP  - 4
DP  - 2005 Oct
TI  - The role of fetal breathing-like movements in lung organogenesis.
PG  - 1261-6
LID - 10.14670/HH-20.1261 [doi]
AB  - In this review the recent findings concerning the role of fetal breathing-like 
      movements (FBMs) on lung organogenesis are discussed. We first review the 
      consequences that the lack of FBMs has on lung organogenesis and then we discuss 
      the possible pathways that may be employed in this process. Specifically, we 
      review the data in support of the notion that FBMs are required for the cell 
      cycle kinetics regulation (i.e., cell proliferation and cell death) via the 
      expression of growth factors, such as platelet derived growth factors (PDGFs) and 
      insulin growth factors (IGFs), and thyroid transcription factor 1 (TTF-1). 
      Moreover, the role of FBMs on biochemical differentiation of Clara cells, type I 
      and type II pneumocytes is reviewed. Interestingly, even though type II 
      pneumocytes are able to synthesize surfactant-associated proteins (SPs), in the 
      complete absence of FBMs, they are unable to compile, store and release the 
      surfactant. Similarly, in spite of the expression of some early differentiation 
      markers, in the absence of FBMs, type I pneumocytes are unable to flatten in 
      order to allow the gas exchange in the lung. In fact, we are currently employing 
      the cDNA microarray analysis in search for the molecules that might be specific 
      for the lacking functions in pneumocytes.
FAU - Inanlou, M R
AU  - Inanlou MR
AD  - Dalhousie University, Faculty of Medicine, Department of Anatomy and Neurobiology 
      Halifax, NS, Canada.
FAU - Baguma-Nibasheka, M
AU  - Baguma-Nibasheka M
FAU - Kablar, B
AU  - Kablar B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Animals
MH  - Fetal Movement/*physiology
MH  - Humans
MH  - Lung/*embryology/growth & development/*physiology
MH  - *Respiration
RF  - 48
EDAT- 2005/09/02 09:00
MHDA- 2006/01/07 09:00
CRDT- 2005/09/02 09:00
PHST- 2005/09/02 09:00 [pubmed]
PHST- 2006/01/07 09:00 [medline]
PHST- 2005/09/02 09:00 [entrez]
AID - 10.14670/HH-20.1261 [doi]
PST - ppublish
SO  - Histol Histopathol. 2005 Oct;20(4):1261-6. doi: 10.14670/HH-20.1261.