PMID- 16136515
OWN - NLM
STAT- MEDLINE
DCOM- 20060106
LR  - 20170327
IS  - 0213-3911 (Print)
IS  - 0213-3911 (Linking)
VI  - 20
IP  - 4
DP  - 2005 Oct
TI  - Hepatocyte growth factor/scatter factor and prostate cancer: a review.
PG  - 1339-49
LID - 10.14670/HH-20.1339 [doi]
AB  - Men who die from prostate cancer do so from uncontrolled metastatic disease. A 
      better understanding of the mechanisms involved in the progression and metastasis 
      of prostate cancer may lead to novel therapeutic approaches to prevent its 
      natural progression. Hepatocyte Growth Factor / Scatter factor (HGF/SF) has been 
      demonstrated to elicit a number of key functions in numerous tissues that are 
      important in the progression, invasion and metastasis of cancer. Studies have 
      demonstrated that the activity of HGF/SF and its receptor c-Met are linked to 
      disease progression in numerous cancers. However, research into these functions, 
      which include activities as a mitogen, a motogen and an anti-apoptotic and 
      angiogenic factor in prostate cancer are limited. This article reviews the 
      published evidence of the roles HGF/SF plays in prostate cancer progression and 
      highlights the clinical and therapeutic potential of research into this 
      pleiomorphic cytokine.
FAU - Hurle, R A
AU  - Hurle RA
AD  - Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College 
      of Medicine, Heath Park, Cardiff. UK. rhidian.hurle@cardiffandvale.wales.nhs.uk
FAU - Davies, G
AU  - Davies G
FAU - Parr, C
AU  - Parr C
FAU - Mason, M D
AU  - Mason MD
FAU - Jenkins, S A
AU  - Jenkins SA
FAU - Kynaston, H G
AU  - Kynaston HG
FAU - Jiang, W G
AU  - Jiang WG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Hepatocyte Growth Factor/antagonists & inhibitors/*physiology
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/*metabolism/pathology
RF  - 95
EDAT- 2005/09/02 09:00
MHDA- 2006/01/07 09:00
CRDT- 2005/09/02 09:00
PHST- 2005/09/02 09:00 [pubmed]
PHST- 2006/01/07 09:00 [medline]
PHST- 2005/09/02 09:00 [entrez]
AID - 10.14670/HH-20.1339 [doi]
PST - ppublish
SO  - Histol Histopathol. 2005 Oct;20(4):1339-49. doi: 10.14670/HH-20.1339.