PMID- 16136551
OWN - NLM
STAT- MEDLINE
DCOM- 20060210
LR  - 20131121
IS  - 0012-1630 (Print)
IS  - 0012-1630 (Linking)
VI  - 47
IP  - 2
DP  - 2005 Sep
TI  - Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature 
      regulation, spontaneous motor activity, attention, and serotonin transporter 
      binding.
PG  - 145-57
AB  - Previous research in our laboratory found that repeated exposure of adolescent 
      rats to 3,4-methylenedioxymethamphetamine (MDMA) impaired working memory and 
      reduced anxiety. The present experiment extended these findings by investigating 
      the physiological, behavioral, and neurotoxic effects of a modified MDMA 
      treatment regimen. Male Sprague-Dawley rats received 5 mg/kg of MDMA hourly for a 
      period of 4 hr on every fifth day from postnatal day 35-60. Acute effects of the 
      MDMA treatment included hypothermia, serotonin syndrome behavior, and 
      ejaculation. Body weight gain was attenuated by repeated drug administration. The 
      animals completed anxiety and working memory tests beginning 4 days after the 
      final MDMA dose. MDMA altered habituation to the open-field, increased locomotor 
      activity in the elevated plus-maze, decreased attention in the novel 
      object-recognition test, and reduced serotonin transporter binding in the 
      neocortex. These results indicate that repeated exposure to a relatively moderate 
      MDMA dose during adolescence produces later changes in behavior and 
      neurochemistry.
CI  - Copyright 2005 Wiley Periodicals, Inc
FAU - Piper, Brian J
AU  - Piper BJ
AD  - Neuroscience and Behavior Program, University of Massachusetts, Amherst, 
      Massachusetts, USA.
FAU - Fraiman, Joseph B
AU  - Fraiman JB
FAU - Meyer, Jerrold S
AU  - Meyer JS
LA  - eng
GR  - T32 NS007490/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - 0 (Serotonin Agents)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Attention/*drug effects
MH  - Body Temperature/drug effects
MH  - Body Temperature Regulation/*drug effects
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Ejaculation/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Protein Binding/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Agents/administration & dosage/toxicity
MH  - Serotonin Plasma Membrane Transport Proteins/*drug effects
MH  - Time Factors
EDAT- 2005/09/02 09:00
MHDA- 2006/02/14 09:00
CRDT- 2005/09/02 09:00
PHST- 2005/09/02 09:00 [pubmed]
PHST- 2006/02/14 09:00 [medline]
PHST- 2005/09/02 09:00 [entrez]
AID - 10.1002/dev.20085 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2005 Sep;47(2):145-57. doi: 10.1002/dev.20085.