PMID- 16136650 OWN - NLM STAT- MEDLINE DCOM- 20051202 LR - 20191210 IS - 0010-4825 (Print) IS - 0010-4825 (Linking) VI - 35 IP - 5 DP - 2005 Jun TI - Determining variability of ophthalmic arterial Doppler signals using Lyapunov exponents. PG - 405-420 AB - The new method presented in this study was directly based on the consideration that ophthalmic arterial Doppler signals are chaotic signals. This consideration was tested successfully using the nonlinear dynamics tools, like the computation of Lyapunov exponents. Multilayer perceptron neural network (MLPNN) architecture was formulated and used as a basis for determining variabilities such as stenosis, ocular Behcet disease, and uveitis disease in the physical state of ophthalmic arterial Doppler signals. The computed Lyapunov exponents of the ophthalmic arterial Doppler signals were used as inputs of the MLPNN. Receiver operating characteristic (ROC) curve was used to assess the performance of the detection process. The ophthalmic arterial Doppler signals were classified with the accuracy varying from 93.75% to 97.06%. The results confirmed that the proposed MLPNN trained with Levenberg-Marquardt algorithm has potential in detecting stenosis, Behcet disease and uveitis disease in ophthalmic arteries. FAU - Ubeyli, Elif Derya AU - Ubeyli ED AD - Department of Electronics and Computer Education, Faculty of Technical Education, Gazi Univeresity, 06500 Teknikokullar, Ankara, Turkey. FAU - Guler, Inan AU - Guler I LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Comput Biol Med JT - Computers in biology and medicine JID - 1250250 SB - IM MH - Adult MH - Aged MH - Algorithms MH - Behcet Syndrome/diagnosis/diagnostic imaging MH - Case-Control Studies MH - *Computer Simulation MH - Diagnosis, Computer-Assisted MH - Female MH - Humans MH - Male MH - Middle Aged MH - Models, Biological MH - Neural Networks, Computer MH - Nonlinear Dynamics MH - ROC Curve MH - Retinal Artery/*diagnostic imaging MH - Retinal Artery Occlusion/diagnosis/diagnostic imaging MH - Ultrasonography, Doppler MH - Uveitis/diagnosis/diagnostic imaging EDAT- 2005/09/02 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/09/02 09:00 PHST- 2005/09/02 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/09/02 09:00 [entrez] AID - S0010-4825(04)00045-9 [pii] AID - 10.1016/j.compbiomed.2004.03.004 [doi] PST - ppublish SO - Comput Biol Med. 2005 Jun;35(5):405-420. doi: 10.1016/j.compbiomed.2004.03.004.