PMID- 16137046
OWN - NLM
STAT- MEDLINE
DCOM- 20070316
LR  - 20050902
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 29
IP  - 5
DP  - 2004 Oct
TI  - [Expression and significance of monocyte chemoattractant protein-i in rat kidney 
      with unilateral ureteral obstruction].
PG  - 558-61
AB  - OBJECTIVE: To investigate the renal expression of monocyte chemoattractant 
      protein-1 (MCP-1) in rat with unilateral ureteral obstruction (UUO) and its 
      association with macrophages infiltration in renal interstitium. METHODS: Sixty 
      female Sprague-Dawley rats were randomized into UUO and sham-operation (SOR) 
      groups. The kidneys were harversted at 1, 4, 7, 10 and 14 d after the operation. 
      Immunohistochemistry was used on the renal tissue for MCP-1 and ED-1 which was a 
      marker of macrophage. Histological changes were also observed by HE and Masson 
      staining. RESULTS: Compared with the SOR group, there was a significant increase 
      in MCP-1, ED-1 expression in the UUO group (P < 0.05). The expression intensity 
      of MCP-1 was correlated with the interstitial macrophages accumulation and 
      interstitial fibrosis (r = 0.865, 0.928, 0.858, 0.893, and 0. 873; r = 0.856, 
      0.896, 0.686, 0.820, and 0.867, respectively; P < 0.05). Interstitial macrophage 
      infiltration was correlated with the grade of interstitial fibrosis too (r = 
      0.942, 0.898, 0.920, 0.914, and 0.829, P < 0.05). CONCLUSION: Elevated MCP-1 
      expression might be responsible for the macrophages infiltration and interstitial 
      fibrosis in the obstructed kidney.
FAU - Chun, Ou-yang
AU  - Chun OY
AD  - Department of Nephrology, Xiangya Hospital, Central South University, Changsha 
      410008, China.
FAU - Ning, Jian-ping
AU  - Ning JP
FAU - Zhou, Qiao-ling
AU  - Zhou QL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Female
MH  - Fibrosis/pathology
MH  - Kidney/pathology
MH  - Kidney Tubules/*metabolism/pathology
MH  - Macrophages/*pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ureteral Obstruction/*metabolism
EDAT- 2005/09/03 09:00
MHDA- 2007/03/17 09:00
CRDT- 2005/09/03 09:00
PHST- 2005/09/03 09:00 [pubmed]
PHST- 2007/03/17 09:00 [medline]
PHST- 2005/09/03 09:00 [entrez]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Oct;29(5):558-61.