PMID- 16137680
OWN - NLM
STAT- MEDLINE
DCOM- 20051205
LR  - 20201209
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 579
IP  - 26
DP  - 2005 Oct 31
TI  - RNA silencing in fungi: mechanisms and applications.
PG  - 5950-7
AB  - Two RNA silencing-related phenomena, quelling and meiotic silencing by unpaired 
      DNA (MSUD) have been identified in the fungus Neurospora crassa. Similar to the 
      case with the siRNA and miRNA pathways in Drosophila, different sets of protein 
      components including RNA-dependent RNA polymerase, argonaute and dicer, are used 
      in the quelling and MSUD pathways. Orthologs of the RNA silencing components are 
      found in most, but not all, fungal genomes currently available in the public 
      databases, indicating that the majority of fungi possess the silencing machinery. 
      Advantage and disadvantage of RNA silencing as a tool to explore gene function in 
      fungi are discussed.
FAU - Nakayashiki, Hitoshi
AU  - Nakayashiki H
AD  - Laboratory of Plant Pathology, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe 
      657-8501, Japan. hnakaya@kobe-u.ac.jp
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20050824
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Fungal)
RN  - 0 (RNA, Small Interfering)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.7.48 (RNA-Dependent RNA Polymerase)
RN  - EC 3.1.26.3 (Ribonuclease III)
SB  - IM
MH  - Animals
MH  - DNA/genetics
MH  - Gene Silencing
MH  - Genetic Techniques
MH  - Genome, Fungal
MH  - Green Fluorescent Proteins/metabolism
MH  - Humans
MH  - Meiosis
MH  - MicroRNAs/metabolism
MH  - Microscopy, Fluorescence
MH  - Models, Biological
MH  - Neurospora
MH  - Neurospora crassa/metabolism
MH  - Phylogeny
MH  - Protein Structure, Tertiary
MH  - *RNA Interference
MH  - RNA, Fungal/*genetics
MH  - RNA, Small Interfering/metabolism
MH  - RNA-Dependent RNA Polymerase/metabolism
MH  - Recombination, Genetic
MH  - Ribonuclease III/chemistry
RF  - 50
EDAT- 2005/09/03 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/09/03 09:00
PHST- 2005/06/13 00:00 [received]
PHST- 2005/08/12 00:00 [revised]
PHST- 2005/08/13 00:00 [accepted]
PHST- 2005/09/03 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/03 09:00 [entrez]
AID - S0014-5793(05)00995-6 [pii]
AID - 10.1016/j.febslet.2005.08.016 [doi]
PST - ppublish
SO  - FEBS Lett. 2005 Oct 31;579(26):5950-7. doi: 10.1016/j.febslet.2005.08.016. Epub 
      2005 Aug 24.