PMID- 16138193
OWN - NLM
STAT- MEDLINE
DCOM- 20051214
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 115
IP  - 9
DP  - 2005 Sep
TI  - Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and 
      remodeling.
PG  - 2508-16
AB  - Ang II is a central mediator of vascular inflammation and remodeling. The 
      transcription factor Ets-1 is rapidly induced in vascular smooth muscle and 
      endothelial cells of the mouse thoracic aorta in response to systemic Ang II 
      infusion. Arterial wall thickening, perivascular fibrosis, and cardiac 
      hypertrophy are significantly diminished in Ets1-/- mice compared with control 
      mice in response to Ang II. The induction of 2 known targets of Ets-1, 
      cyclin-dependent kinase inhibitor p21CIP and plasminogen activator inhibitor-1 
      (PAI-1), by Ang II is markedly blunted in the aorta of Ets1-/- mice compared with 
      wild-type controls. Expression of p21CIP in VSMCs leads to cellular hypertrophy, 
      whereas expression of p21CIP in endothelial cells is associated with cell cycle 
      arrest, apoptosis, and endothelial dysfunction. PAI-1 promotes the development of 
      perivascular fibrosis. We have identified monocyte chemoattractant protein-1 
      (MCP-1) as a novel target for Ets-1. Expression of MCP-1 is similarly reduced in 
      Ets1-/- mice compared with control mice in response to Ang II, which results in 
      significantly diminished recruitment of T cells and macrophages to the vessel 
      wall. In summary, our results support a critical role for Ets-1 as a 
      transcriptional mediator of vascular inflammation and remodeling in response to 
      Ang II.
FAU - Zhan, Yumei
AU  - Zhan Y
AD  - Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes 
      of Medicine, Boston, Massachusetts 02115, USA.
FAU - Brown, Courtney
AU  - Brown C
FAU - Maynard, Elizabeth
AU  - Maynard E
FAU - Anshelevich, Aleksandra
AU  - Anshelevich A
FAU - Ni, Weihua
AU  - Ni W
FAU - Ho, I-Cheng
AU  - Ho IC
FAU - Oettgen, Peter
AU  - Oettgen P
LA  - eng
GR  - P01 HL076540/HL/NHLBI NIH HHS/United States
GR  - R01 HL067219/HL/NHLBI NIH HHS/United States
GR  - HL-67219/HL/NHLBI NIH HHS/United States
GR  - P01 HL76540-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Cdkn1a protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Ets1 protein, mouse)
RN  - 0 (Interleukin-6)
RN  - 0 (Klf5 protein, mouse)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Proto-Oncogene Protein c-ets-1)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
CIN - J Clin Invest. 2005 Sep;115(9):2319-22. PMID: 16138186
MH  - Angiotensin II/*metabolism
MH  - Animals
MH  - *Aorta/anatomy & histology/immunology/metabolism/pathology
MH  - Blood Pressure
MH  - Cells, Cultured
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Interleukin-6/metabolism
MH  - Kruppel-Like Transcription Factors/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Plasminogen Activator Inhibitor 1/genetics/metabolism
MH  - Proto-Oncogene Protein c-ets-1/genetics/*metabolism
MH  - Tissue Plasminogen Activator/metabolism
MH  - Vascular Cell Adhesion Molecule-1/metabolism
PMC - PMC1193876
EDAT- 2005/09/03 09:00
MHDA- 2005/12/15 09:00
PMCR- 2005/09/01
CRDT- 2005/09/03 09:00
PHST- 2005/01/05 00:00 [received]
PHST- 2005/06/14 00:00 [accepted]
PHST- 2005/09/03 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/09/03 09:00 [entrez]
PHST- 2005/09/01 00:00 [pmc-release]
AID - 24403 [pii]
AID - 10.1172/JCI24403 [doi]
PST - ppublish
SO  - J Clin Invest. 2005 Sep;115(9):2508-16. doi: 10.1172/JCI24403.