PMID- 16138730
OWN - NLM
STAT- MEDLINE
DCOM- 20051004
LR  - 20170214
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 24
IP  - 8
DP  - 2005 Aug
TI  - Developmental exposure to fenproporex: reproductive and morphological evaluation.
PG  - 397-402
AB  - This study was designed to evaluate the maternal toxicity and teratogenicity of 
      fenproporex, one of the most widely-used anorectic drugs in many countries, 
      including Brazil. Three periods of exposure were evaluated: (a) 30 days before 
      mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and 
      during pregnancy, until GD 14. Female mice from experimental groups received, by 
      gavage, 15 mg/kg of fenproporex. Treatment with fenproporex increased ambulation 
      of dams in the open-field test and did not influence the mobility in the 
      forced-swimming test. There was no significant difference in maternal weight gain 
      between the controls and fenproporex-treated groups, although fenproporex 
      treatment reduced the gravid uterus weight. No significant difference was 
      observed in postimplantation loss, fetal viability and sex ratio. In addition, 
      this compound did not impair intra-uterine growth. The reduction in the number of 
      implantations in the groups receiving fenproporex indicates that this drug may 
      have an adverse effect on implantation. Fenproporex treatment also increased the 
      number of fetuses presenting small kidneys and cervical ribs. The present results 
      indicate that fenproporex, in the dose and exposure periods tested, appears to 
      exhibit a low maternal toxicity and teratogenic potential in mice.
FAU - Moreira, C Q
AU  - Moreira CQ
AD  - Department of Biology, Center of Biological Sciences, Londrina State University, 
      Londrina, PR, Brazil.
FAU - Faria, M J S S
AU  - Faria MJ
FAU - Baroneza, J E
AU  - Baroneza JE
FAU - Oliveira, R J
AU  - Oliveira RJ
FAU - Moreira, E G
AU  - Moreira EG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Amphetamines)
RN  - 0 (Appetite Depressants)
RN  - 0 (Teratogens)
RN  - W0194S5FOA (fenproporex)
SB  - IM
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Appetite Depressants/*toxicity
MH  - Female
MH  - Male
MH  - *Maternal Exposure
MH  - Mice
MH  - Pregnancy
MH  - Teratogens/*toxicity
EDAT- 2005/09/06 09:00
MHDA- 2005/10/05 09:00
CRDT- 2005/09/06 09:00
PHST- 2005/09/06 09:00 [pubmed]
PHST- 2005/10/05 09:00 [medline]
PHST- 2005/09/06 09:00 [entrez]
AID - 10.1191/0960327105ht545oa [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2005 Aug;24(8):397-402. doi: 10.1191/0960327105ht545oa.