PMID- 16139846
OWN - NLM
STAT- MEDLINE
DCOM- 20051215
LR  - 20171116
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 78
IP  - 4
DP  - 2005 Dec 12
TI  - Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and 
      streptozotocin-induced diabetic rats.
PG  - 406-12
AB  - We investigated the antihyperglycemic effect of p-methoxycinnamic acid (p-MCA), a 
      cinnamic acid derivative, on plasma glucose and insulin concentrations, 
      activities of hepatic glucose-regulating enzymes and hepatic glycogen content in 
      normal and streptozotocin (STZ)-induced diabetic rats. p-MCA (10-100 mg/kg, PO) 
      dose-dependently decreased plasma glucose concentration in both normal and 
      diabetic rats in the oral glucose tolerance test. To investigate the chronic 
      effects of p-MCA on glucose metabolism, p-MCA (40 mg/kg, PO) was administered to 
      normal and diabetic rats once a day for 4 weeks. p-MCA reduced plasma glucose 
      concentration in diabetic rats, which was observed during the 4-week study. 
      However, p-MCA treatment did not change plasma glucose concentrations in normal 
      rats during the 4-week study. p-MCA also reduced the excessive activities of 
      hepatic glucose-6-phosphatase, hepatic hexokinase, glucokinase and 
      phosphofructokinase in diabetic rats and increased hepatic glycogen in these 
      rats. In p-MCA-treated normal rats, there were no changes in the activities of 
      hepatic glucose-regulating enzymes, hepatic glycogen and glucose-6-phosphate. Our 
      findings suggested that p-MCA exert its antihyperglycemic effect by increasing 
      insulin secretion and glycolysis, and by decreasing gluconeogenesis.
FAU - Adisakwattana, Sirichai
AU  - Adisakwattana S
AD  - Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn 
      University. Henridunant-Rd. Pathumwan, Bangkok 10330, Thailand.
FAU - Roengsamran, Sophon
AU  - Roengsamran S
FAU - Hsu, Walter H
AU  - Hsu WH
FAU - Yibchok-anun, Sirintorn
AU  - Yibchok-anun S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050902
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Blood Glucose)
RN  - 0 (Cinnamates)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Liver Glycogen)
RN  - 6G4ML8401A (4-methoxycinnamic acid)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Cinnamates/*therapeutic use
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Glucose Tolerance Test
MH  - Glucose-6-Phosphatase/metabolism
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Liver/drug effects/enzymology
MH  - Liver Glycogen/metabolism
MH  - Male
MH  - Phosphotransferases (Alcohol Group Acceptor)/metabolism
MH  - Rats
EDAT- 2005/09/06 09:00
MHDA- 2005/12/16 09:00
CRDT- 2005/09/06 09:00
PHST- 2005/01/25 00:00 [received]
PHST- 2005/04/29 00:00 [accepted]
PHST- 2005/09/06 09:00 [pubmed]
PHST- 2005/12/16 09:00 [medline]
PHST- 2005/09/06 09:00 [entrez]
AID - S0024-3205(05)00776-9 [pii]
AID - 10.1016/j.lfs.2005.04.073 [doi]
PST - ppublish
SO  - Life Sci. 2005 Dec 12;78(4):406-12. doi: 10.1016/j.lfs.2005.04.073. Epub 2005 Sep 
      2.