PMID- 16140553
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20221207
IS  - 1096-7192 (Print)
IS  - 1096-7192 (Linking)
VI  - 87
IP  - 1
DP  - 2006 Jan
TI  - Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an 
      African American population.
PG  - 54-60
AB  - African Americans (AA) are at increased risk for developing type 2 diabetes 
      mellitus (T2DM) relative to European Americans. We previously detected linkage of 
      T2DM to 6q24-q27 (LOD 2.26) at 163.5 cM, closest to marker D6S1035, in a 
      genome-wide scan of AA families. The mu-opioid receptor gene (OPRM1) is located 
      within the LOD-1 support interval of this linkage peak. OPRM1 is an attractive 
      positional candidate gene for T2DM susceptibility since agonists of OPRM1 affect 
      glucose-induced insulin release and OPRM1 knockout mice have a more rapid 
      induction of insulin resistance than wild-type. Twenty-two SNPs in this gene, at 
      an average spacing of 3.9 kb, were genotyped in 380 AA T2DM cases and 276 AA 
      controls. In single SNP association analyses, rs648007 demonstrated significant 
      evidence of association with T2DM (P=0.013). Four blocks of high linkage 
      disequilibrium were detected across the OPRM1 gene. Association analyses of 
      haplotypes in each of these blocks revealed two haplotype blocks with significant 
      overall P values (P=0.007 and 0.046). Significant, but rare, risk and protective 
      haplotypes were identified as driving these associations with T2DM 
      (P=0.034-0.047). These associations suggest that the OPRM1 gene plays a role in 
      T2DM susceptibility in African Americans.
FAU - Gallagher, Carla J
AU  - Gallagher CJ
AD  - Department of Biochemistry, Wake Forest University School of Medicine, 
      Winston-Salem, NC 27157, USA.
FAU - Gordon, Candace J
AU  - Gordon CJ
FAU - Langefeld, Carl D
AU  - Langefeld CD
FAU - Mychaleckyj, Josyf C
AU  - Mychaleckyj JC
FAU - Freedman, Barry I
AU  - Freedman BI
FAU - Rich, Stephen S
AU  - Rich SS
FAU - Bowden, Donald W
AU  - Bowden DW
FAU - Sale, Michele M
AU  - Sale MM
LA  - eng
GR  - R01 DK066358/DK/NIDDK NIH HHS/United States
GR  - R01 DK53591/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20050902
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
RN  - 0 (Receptors, Opioid, mu)
SB  - IM
MH  - Black or African American/*genetics
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Kidney Failure, Chronic/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Opioid, mu/*genetics
EDAT- 2005/09/06 09:00
MHDA- 2006/03/03 09:00
CRDT- 2005/09/06 09:00
PHST- 2005/07/19 00:00 [received]
PHST- 2005/07/19 00:00 [accepted]
PHST- 2005/09/06 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/09/06 09:00 [entrez]
AID - S1096-7192(05)00224-6 [pii]
AID - 10.1016/j.ymgme.2005.07.013 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2006 Jan;87(1):54-60. doi: 10.1016/j.ymgme.2005.07.013. Epub 
      2005 Sep 2.