PMID- 16142239
OWN - NLM
STAT- MEDLINE
DCOM- 20051102
LR  - 20171116
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 6
IP  - 10
DP  - 2005 Oct
TI  - Interaction between conventional dendritic cells and natural killer cells is 
      integral to the activation of effective antiviral immunity.
PG  - 1011-9
AB  - Dendritic cells (DCs) regulate various aspects of innate immunity, including 
      natural killer (NK) cell function. Here we define the mechanisms involved in 
      DC-NK cell interactions during viral infection. NK cells were efficiently 
      activated by murine cytomegalovirus (MCMV)-infected CD11b(+) DCs. NK cell 
      cytotoxicity required interferon-alpha and interactions between the NKG2D 
      activating receptor and NKG2D ligand, whereas the production of interferon-gamma 
      by NK cells relied mainly on DC-derived interleukin 18. Although Toll-like 
      receptor 9 contributes to antiviral immunity, we found that signaling pathways 
      independent of Toll-like receptor 9 were important in generating immune responses 
      to MCMV, including the production of interferon-alpha and the induction of NK 
      cell cytotoxicity. Notably, adoptive transfer of MCMV-activated CD11b(+) DCs 
      resulted in improved control of MCMV infection, indicating that these cells 
      participate in controlling viral replication in vivo.
FAU - Andoniou, Christopher E
AU  - Andoniou CE
AD  - Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The 
      University of Western Australia, Crowley 6009, Western Australia, Australia.
FAU - van Dommelen, Serani L H
AU  - van Dommelen SL
FAU - Voigt, Valentina
AU  - Voigt V
FAU - Andrews, Daniel M
AU  - Andrews DM
FAU - Brizard, Geraldine
AU  - Brizard G
FAU - Asselin-Paturel, Carine
AU  - Asselin-Paturel C
FAU - Delale, Thomas
AU  - Delale T
FAU - Stacey, Katryn J
AU  - Stacey KJ
FAU - Trinchieri, Giorgio
AU  - Trinchieri G
FAU - Degli-Esposti, Mariapia A
AU  - Degli-Esposti MA
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050904
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (CD11 Antigens)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukin-18)
RN  - 0 (Klrk1 protein, mouse)
RN  - 0 (Ligands)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily K)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Natural Killer Cell)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - CD11 Antigens/biosynthesis
MH  - Cytotoxicity, Immunologic
MH  - Dendritic Cells/*immunology
MH  - Herpesviridae Infections/*immunology
MH  - Interferon-alpha/biosynthesis
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Muromegalovirus/*immunology
MH  - NK Cell Lectin-Like Receptor Subfamily K
MH  - Receptors, Immunologic/metabolism
MH  - Receptors, Natural Killer Cell
EDAT- 2005/09/06 09:00
MHDA- 2005/11/03 09:00
CRDT- 2005/09/06 09:00
PHST- 2005/05/08 00:00 [received]
PHST- 2005/07/27 00:00 [accepted]
PHST- 2005/09/06 09:00 [pubmed]
PHST- 2005/11/03 09:00 [medline]
PHST- 2005/09/06 09:00 [entrez]
AID - ni1244 [pii]
AID - 10.1038/ni1244 [doi]
PST - ppublish
SO  - Nat Immunol. 2005 Oct;6(10):1011-9. doi: 10.1038/ni1244. Epub 2005 Sep 4.