PMID- 16142858
OWN - NLM
STAT- MEDLINE
DCOM- 20051115
LR  - 20151119
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 32
IP  - 9
DP  - 2005 Sep
TI  - Histological patterns of synovitis and serum chemokines in patients with 
      rheumatoid arthritis.
PG  - 1666-72
AB  - OBJECTIVE: Studies indicate the genetic, biological, and clinical heterogeneity 
      of rheumatoid arthritis (RA). Recently the histological diversity of RA has been 
      postulated. We investigated whether serum concentrations of interleukin 8 (IL-8), 
      RANTES (regulated upon activation normal T cell expressed and secreted), and 
      monocyte chemoattractant protein-1 (MCP-1) are correlated with histological 
      appearance of the rheumatoid synovitis. METHODS: Using ELISA we assessed IL-8, 
      RANTES, and MCP-1 concentrations in serum of 47 patients with RA and 30 patients 
      with osteoarthritis (OA). RESULTS: Morphological analysis of synovial specimens 
      distinguished 2 types of rheumatoid synovitis. Twenty-eight RA samples presented 
      diffuse infiltrates of mononuclear cells with no specific microanatomical 
      organization and were categorized as diffuse synovitis. In the remaining 19 
      specimens, classified as follicular synovitis, formation of lymphocytic follicles 
      with germinal center-like structures was observed. Serum levels of studied 
      chemokines were increased in patients with RA compared to the OA control group (p 
      < 0.001 for all comparisons). Concentrations of IL-8, RANTES, and MCP-1 were 
      highest in serum of RA patients with follicular synovitis in comparison with 
      patients with diffuse synovitis (p < 0.01, p < 0.01, and p < 0.05, respectively) 
      and could distinguish RA patients with these 2 histological disease patterns. 
      Serum levels of chemokines correlated with markers of disease activity such as 
      erythrocyte sedimentation rate, C-reactive protein concentrations, and Disease 
      Activity Score. CONCLUSION: Distinct histological variants of rheumatoid 
      synovitis associated with different serum levels of IL-8, RANTES, and MCP-1 
      reflect clinical activity of the disease and confirm the concept of RA 
      heterogeneity.
FAU - Klimiuk, Piotr Adrian
AU  - Klimiuk PA
AD  - Department of Rheumatology and Internal Diseases, Medical University of 
      Bialystok, Bialystok, Poland. klimp@amb.edu.pl
FAU - Sierakowski, Stanislaw
AU  - Sierakowski S
FAU - Latosiewicz, Robert
AU  - Latosiewicz R
FAU - Skowronski, Jan
AU  - Skowronski J
FAU - Cylwik, Jacek Przemyslaw
AU  - Cylwik JP
FAU - Cylwik, Bohdan
AU  - Cylwik B
FAU - Chwiecko, Justyna
AU  - Chwiecko J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*blood/*pathology/physiopathology
MH  - Biomarkers/blood
MH  - Biopsy, Needle
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL5/blood
MH  - Chemokines/*blood/metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Prognosis
MH  - Reference Values
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Synovitis/blood/*pathology/physiopathology
EDAT- 2005/09/06 09:00
MHDA- 2005/11/16 09:00
CRDT- 2005/09/06 09:00
PHST- 2005/09/06 09:00 [pubmed]
PHST- 2005/11/16 09:00 [medline]
PHST- 2005/09/06 09:00 [entrez]
AID - 0315162X-32-1666 [pii]
PST - ppublish
SO  - J Rheumatol. 2005 Sep;32(9):1666-72.