PMID- 16144212
OWN - NLM
STAT- MEDLINE
DCOM- 20051207
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 28
IP  - 8
DP  - 2005 Aug
TI  - Proton pump inhibitors for patients with coronary artery disease associated with 
      reduced chest pain, emergency department visits, and hospitalizations.
PG  - 369-74
AB  - BACKGROUND: Patients with coronary artery disease (CAD) presenting to an 
      emergency department (ED) with chest pain are likely to undergo hospitalization 
      as clinicians attempt to elucidate the etiology. HYPOTHESIS: We hypothesized that 
      proton pump inhibitor (PPI) therapy is associated with reduced chest pain events 
      and evaluations in patients with CAD. METHODS: A patient population from a 
      veterans medical center with documented CAD was identified retrospectively, and 
      chest pain episodes, ED visits, and hospitalizations for chest pain were 
      prospectively followed over 2 years. Comparison of patient outcomes between PPI 
      (+PPI) and nonuse of PPI therapy (-PPI) was determined. RESULTS: Of 415 male 
      patients, average age 73.4 years, 23% utilized a PPI and 77% did not. Proton pump 
      inhibitor therapy was associated with reduced chest pain episodes (11.8 vs. 
      26.2%, p = 0.002), ED visits (12.3 vs. 24.3%, p = 0.044), and hospitalizations 
      (12.8 vs. 23.9%, p = 0.086). Relative reductions were 55, 49, and 46%, 
      respectively, after 2 years. Numbers of adverse events were also decreased in the 
      +PPI group of patients: 70% fewer occurrences of chest pain (p = 0.002, relative 
      risk [RR] = 3.3), 55% fewer ED visits (p = 0.049, RR = 2.2), and 53% fewer 
      hospitalizations (p = 0.064, RR = 2.1). By multivariate analysis, PPI therapy 
      independently predicted reduced prevalence of patients experiencing chest pain, 
      ED visits, or hospitalizations (odds ratio [OR] = 0.09 [0.04-0.21]; 0.15 
      [0.06-0.40]; 0.14 [0.05-0.40]; all p < 0.001). CONCLUSIONS: Proton pump inhibitor 
      therapy for male patients with CAD from a veterans medical center was associated 
      with reduced prevalence of chest pain, ED visits, and hospitalizations for chest 
      pain and reduced incidence of these events.
FAU - Liuzzo, John P
AU  - Liuzzo JP
AD  - Department of Medicine, Division of Cardiology, Saint Vincent Catholic Medical 
      Centers, Comprehensive Cardiovascular Center, New York, NY 10011, USA. 
      jliu2006@yahoo.com
FAU - Ambrose, John A
AU  - Ambrose JA
FAU - Diggs, Paul
AU  - Diggs P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Chest Pain/prevention & control
MH  - Coronary Disease/*drug therapy/epidemiology
MH  - Emergency Service, Hospital/*statistics & numerical data
MH  - Gastroesophageal Reflux/epidemiology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - *Proton Pump Inhibitors
MH  - Retrospective Studies
PMC - PMC6654347
EDAT- 2005/09/08 09:00
MHDA- 2005/12/13 09:00
PMCR- 2006/12/05
CRDT- 2005/09/08 09:00
PHST- 2005/09/08 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/09/08 09:00 [entrez]
PHST- 2006/12/05 00:00 [pmc-release]
AID - CLC4960280805 [pii]
AID - 10.1002/clc.4960280805 [doi]
PST - ppublish
SO  - Clin Cardiol. 2005 Aug;28(8):369-74. doi: 10.1002/clc.4960280805.