PMID- 16144690
OWN - NLM
STAT- MEDLINE
DCOM- 20060714
LR  - 20161124
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 16
IP  - 4-5
DP  - 2005 Aug-Oct
TI  - Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from 
      retinal degeneration.
PG  - 531-8
AB  - Hypoxic exposure of cells or organisms induces expression of a number of hypoxia 
      responsive genes through the activation of the hypoxia-inducible factor-1 
      (HIF-1). One of the most prominent HIF-1 targets is erythropoietin that has 
      beneficial effects on ischemia-related injury in the brain. Exposure to low 
      environmental oxygen concentrations can be used as a preconditioning paradigm to 
      protect cells or tissues against a variety of harmful conditions. Here, we 
      summarize recent work on neuroprotection of retinal photoreceptors and ganglion 
      cells induced by hypoxic preconditioning or by systemically elevated levels of 
      Epo in mouse plasma.
FAU - Grimm, C
AU  - Grimm C
AD  - Laboratory of Retinal Cell Biology, University Eye Hospital Zurich, CH-8091 
      Zurich, Switzerland. cgrimm@opht.unizh.ch
FAU - Hermann, D M
AU  - Hermann DM
FAU - Bogdanova, A
AU  - Bogdanova A
FAU - Hotop, S
AU  - Hotop S
FAU - Kilic, U
AU  - Kilic U
FAU - Wenzel, A
AU  - Wenzel A
FAU - Kilic, E
AU  - Kilic E
FAU - Gassmann, M
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20050418
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Animals
MH  - Erythropoietin/biosynthesis/genetics/*physiology
MH  - Humans
MH  - Hypoxia/*metabolism/pathology/physiopathology
MH  - Retinal Degeneration/*metabolism/pathology/*prevention & control
MH  - Retinal Ganglion Cells/metabolism/pathology
RF  - 55
EDAT- 2005/09/08 09:00
MHDA- 2006/07/15 09:00
CRDT- 2005/09/08 09:00
PHST- 2005/09/08 09:00 [pubmed]
PHST- 2006/07/15 09:00 [medline]
PHST- 2005/09/08 09:00 [entrez]
AID - S1084-9521(05)00056-X [pii]
AID - 10.1016/j.semcdb.2005.03.004 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):531-8. doi: 
      10.1016/j.semcdb.2005.03.004. Epub 2005 Apr 18.