PMID- 16146607
OWN - NLM
STAT- MEDLINE
DCOM- 20090807
LR  - 20050908
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 17
IP  - 9
DP  - 2005 Sep
TI  - [Apoptosis of neutrophil in peripheral blood in experimental sepsis].
PG  - 561-4
AB  - OBJECTIVE: To evaluate the changes in apoptosis of neutrophil in peripheral blood 
      in sepsis in rats. METHODS: The rat sepsis model was reproduced by cecum ligation 
      and puncture (CLP). One hundred and forty-four rats were randomly divided into 
      normal control group, sham operation group and 2, 6, 12, 24, 48, 72 hours after 
      CLP groups. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling 
      (TUNEL) was used to identify neutrophil apoptosis. RESULTS: In early period after 
      CLP, neutrophil apoptosis in peripheral blood was limited with a positive rate of 
      less than 5.00%. The positive rate rose to (48.33+/-12.53)% at 48 hours, and it 
      began to lower, approaching the normal level at 72 hours after CLP. CONCLUSION: 
      Death is the main pathway of loss of neutrophils which are produced in the acute 
      phase of sepsis, and apoptosis is the main pathway of loss of neutrophil in the 
      later phase of sepsis.
FAU - Xi, Jian-cheng
AU  - Xi JC
AD  - Department of Orthopaedics, the 309 th Hospital of PLA, Beijing 100091, China.
FAU - Zhou, Bao-tong
AU  - Zhou BT
FAU - Jiang, Li-xian
AU  - Jiang LX
FAU - Jiang, Xiao-guo
AU  - Jiang XG
FAU - Sun, Tong-zhu
AU  - Sun TZ
FAU - Yang, Yi
AU  - Yang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Disease Models, Animal
MH  - Male
MH  - Neutrophils/*pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Sepsis/*blood
EDAT- 2005/09/09 09:00
MHDA- 2009/08/08 09:00
CRDT- 2005/09/09 09:00
PHST- 2005/09/09 09:00 [pubmed]
PHST- 2009/08/08 09:00 [medline]
PHST- 2005/09/09 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Sep;17(9):561-4.